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Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans

Author

Listed:
  • Surender Khurana

    (FDA)

  • Megan Hahn

    (FDA)

  • Elizabeth M. Coyle

    (FDA)

  • Lisa R. King

    (FDA)

  • Tsai-Lien Lin

    (FDA)

  • John Treanor

    (University of Rochester Medical Center)

  • Andrea Sant

    (University of Rochester Medical Center)

  • Hana Golding

    (FDA)

Abstract

Several vaccines are approved in the United States for seasonal influenza vaccination every year. Here we compare the impact of repeat influenza vaccination on hemagglutination inhibition (HI) titers, antibody binding and affinity maturation to individual hemagglutinin (HA) domains, HA1 and HA2, across vaccine platforms. Fold change in HI and antibody binding to HA1 trends higher for H1N1pdm09 and H3N2 but not against B strains in groups vaccinated with FluBlok compared with FluCelvax and Fluzone. Antibody-affinity maturation occurs against HA1 domain of H1N1pdm09, H3N2 and B following vaccination with all vaccine platforms, but not against H1N1pdm09-HA2. Importantly, prior year vaccination of subjects receiving repeat vaccinations demonstrated reduced antibody-affinity maturation to HA1 of all three influenza virus strains irrespective of the vaccine platform. This study identifies an important impact of repeat vaccination on antibody-affinity maturation following vaccination, which may contribute to lower vaccine effectiveness of seasonal influenza vaccines in humans

Suggested Citation

  • Surender Khurana & Megan Hahn & Elizabeth M. Coyle & Lisa R. King & Tsai-Lien Lin & John Treanor & Andrea Sant & Hana Golding, 2019. "Repeat vaccination reduces antibody affinity maturation across different influenza vaccine platforms in humans," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11296-5
    DOI: 10.1038/s41467-019-11296-5
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    Cited by:

    1. Surender Khurana & Gabrielle Grubbs & Supriya Ravichandran & Emily Cluff & JungHyun Kim & Ana I. Kuehne & Samantha Zak & John M. Dye & Julius J. Lutwama & Andrew S. Herbert, 2024. "Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ji Wang & Caiguangxi Deng & Ming Liu & Yihao Liu & Liubing Li & Zhangping Huang & Liru Shang & Juan Jiang & Yongyong Li & Ruohui Mo & Hui Zhang & Min Liu & Sui Peng & Haipeng Xiao, 2022. "A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Feng Liu & F. Liaini Gross & Sneha Joshi & Manjusha Gaglani & Allison L. Naleway & Kempapura Murthy & Holly C. Groom & Meredith G. Wesley & Laura J. Edwards & Lauren Grant & Sara S. Kim & Suryaprakash, 2024. "Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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