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A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles

Author

Listed:
  • Hao Zheng

    (Fudan University)

  • Zhitao Zhang

    (Fudan University)

  • Su Jiang

    (Fudan University)

  • Biao Yan

    (Fudan University)

  • Xiang Shi

    (Fudan University)

  • Yuanting Xie

    (Fudan University)

  • Xu Huang

    (Fudan University)

  • Zeyang Yu

    (School of Engineering, Brown University)

  • Huizhu Liu

    (Fudan University)

  • Shijun Weng

    (Fudan University)

  • Arto Nurmikko

    (School of Engineering, Brown University)

  • Yuqiu Zhang

    (Fudan University)

  • Huisheng Peng

    (Fudan University)

  • Wendong Xu

    (Fudan University)

  • Jiayi Zhang

    (Fudan University)

Abstract

We previously demonstrated that for long-term spastic limb paralysis, transferring the seventh cervical nerve (C7) from the nonparalyzed side to the paralyzed side results in increase of 17.7 in Fugl-Meyer score. One strategy for further improvement in voluntary arm movement is selective activation of five target muscles innervated by C7 during recovery process. In this study, we develop an implantable multisite optogenetic stimulation device (MOSD) based on shape-memory polymer. Two-site stimulation of sciatic nerve bundles by MOSD induces precise extension or flexion movements of the ankle joint, while eight-site stimulation of C7 nerve bundles induce selective limb movement. Long-term implant of MOSD to mice with severed and anastomosed C7 nerve is proven to be both safe and effective. Our work opens up the possibility for multisite nerve bundle stimulation to induce highly-selective activations of limb muscles, which could inspire further applications in neurosurgery and neuroscience research.

Suggested Citation

  • Hao Zheng & Zhitao Zhang & Su Jiang & Biao Yan & Xiang Shi & Yuanting Xie & Xu Huang & Zeyang Yu & Huizhu Liu & Shijun Weng & Arto Nurmikko & Yuqiu Zhang & Huisheng Peng & Wendong Xu & Jiayi Zhang, 2019. "A shape-memory and spiral light-emitting device for precise multisite stimulation of nerve bundles," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10418-3
    DOI: 10.1038/s41467-019-10418-3
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    Cited by:

    1. Tong Li & Zhidong Wei & Fei Jin & Yongjiu Yuan & Weiying Zheng & Lili Qian & Hongbo Wang & Lisha Hua & Juan Ma & Huanhuan Zhang & Huaduo Gu & Michael G. Irwin & Ting Wang & Steven Wang & Zuankai Wang , 2023. "Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Yi Xing & Mingjie Zhou & Yueguang Si & Chi-Yuan Yang & Liang-Wen Feng & Qilin Wu & Fei Wang & Xiaomin Wang & Wei Huang & Yuhua Cheng & Ruilin Zhang & Xiaozheng Duan & Jun Liu & Ping Song & Hengda Sun , 2023. "Integrated opposite charge grafting induced ionic-junction fiber," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Lin Zhang & Sicheng Xing & Haifeng Yin & Hannah Weisbecker & Hiep Thanh Tran & Ziheng Guo & Tianhong Han & Yihang Wang & Yihan Liu & Yizhang Wu & Wanrong Xie & Chuqi Huang & Wei Luo & Michael Demaessc, 2024. "Skin-inspired, sensory robots for electronic implants," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Kyowon Kang & Seongryeol Ye & Chanho Jeong & Jinmo Jeong & Yeong-sinn Ye & Jin-Young Jeong & Yu-Jin Kim & Selin Lim & Tae Hee Kim & Kyung Yeun Kim & Jong Uk Kim & Gwan In Kim & Do Hoon Chun & Kiho Kim, 2024. "Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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