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Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

Author

Listed:
  • Samuel E. Jones

    (University of Exeter)

  • Vincent T. Hees

    (Netherlands eScience Center)

  • Diego R. Mazzotti

    (University of Pennsylvania
    Perelman School of Medicine of the University of Pennsylvania)

  • Pedro Marques-Vidal

    (Lausanne University Hospital)

  • Séverine Sabia

    (University College London
    INSERM, U1153, Epidemiology of Ageing and Neurodegenerative diseases, Université de Paris)

  • Ashley Spek

    (Erasmus MC University Medical Center)

  • Hassan S. Dashti

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Jorgen Engmann

    (Research department of Population Science and Experimental Medicine, Centre for Translational Genomics)

  • Desana Kocevska

    (Erasmus MC University Medical Center
    Erasmus Medical Center)

  • Jessica Tyrrell

    (University of Exeter)

  • Robin N. Beaumont

    (University of Exeter)

  • Melvyn Hillsdon

    (University of Exeter)

  • Katherine S. Ruth

    (University of Exeter)

  • Marcus A. Tuke

    (University of Exeter)

  • Hanieh Yaghootkar

    (University of Exeter)

  • Seth A. Sharp

    (University of Exeter)

  • Yingjie Ji

    (University of Exeter)

  • Jamie W. Harrison

    (University of Exeter)

  • Rachel M. Freathy

    (University of Exeter)

  • Anna Murray

    (University of Exeter)

  • Annemarie I. Luik

    (Erasmus MC University Medical Center)

  • Najaf Amin

    (Erasmus MC University Medical Center)

  • Jacqueline M. Lane

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Richa Saxena

    (Massachusetts General Hospital
    Massachusetts General Hospital and Harvard Medical School
    Harvard Medical School)

  • Martin K. Rutter

    (University of Manchester
    Manchester Diabetes Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre)

  • Henning Tiemeier

    (Erasmus MC University Medical Center
    Harvard TH Chan School of Public Health)

  • Zoltán Kutalik

    (Lausanne University Hospital
    Swiss Institute of Bioinformatics)

  • Meena Kumari

    (University of Essex, Colchester)

  • Timothy M. Frayling

    (University of Exeter)

  • Michael N. Weedon

    (University of Exeter)

  • Philip R. Gehrman

    (University of Pennsylvania
    Perelman School of Medicine of the University of Pennsylvania)

  • Andrew R. Wood

    (University of Exeter)

Abstract

Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P

Suggested Citation

  • Samuel E. Jones & Vincent T. Hees & Diego R. Mazzotti & Pedro Marques-Vidal & Séverine Sabia & Ashley Spek & Hassan S. Dashti & Jorgen Engmann & Desana Kocevska & Jessica Tyrrell & Robin N. Beaumont &, 2019. "Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09576-1
    DOI: 10.1038/s41467-019-09576-1
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    Cited by:

    1. Matthew C. Pahl & Claudia A. Doege & Kenyaita M. Hodge & Sheridan H. Littleton & Michelle E. Leonard & Sumei Lu & Rick Rausch & James A. Pippin & Maria Caterina Rosa & Alisha Basak & Jonathan P. Bradf, 2021. "Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Pengfei Xu & Dazhi Wang & Jianqiao He & Yichang Cui & Liangkun Lu & Yikang Li & Xiangji Chen & Chang Liu & Liujia Suo & Tongqun Ren & Tiesheng Wang & Yan Cui, 2024. "A zinc oxide resonant nano-accelerometer with ultra-high sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    3. Anders M. Fjell & Øystein Sørensen & Yunpeng Wang & Inge K. Amlien & William F. C. Baaré & David Bartrés-Faz & Lars Bertram & Carl-Johan Boraxbekk & Andreas M. Brandmaier & Ilja Demuth & Christian A. , 2023. "No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy," Nature Human Behaviour, Nature, vol. 7(11), pages 2008-2022, November.
    4. Raphael Vallat & Sarah E. Berry & Neli Tsereteli & Joan Capdevila & Haya Al Khatib & Ana M. Valdes & Linda M. Delahanty & David A. Drew & Andrew T. Chan & Jonathan Wolf & Paul W. Franks & Tim D. Spect, 2022. "How people wake up is associated with previous night’s sleep together with physical activity and food intake," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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