IDEAS home Printed from https://ideas.repec.org/a/hin/jnlnrp/410395.html
   My bibliography  Save this article

A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans

Author

Listed:
  • Teresa N. Brockie
  • Morgan Heinzelmann
  • Jessica Gill

Abstract

Background . Native Americans disproportionately experience adverse childhood experiences (ACEs) as well as health disparities, including high rates of posttraumatic stress, depression, and substance abuse. Many ACEs have been linked to methylation changes in genes that regulate the stress response, suggesting that these molecular changes may underlie the risk for psychiatric disorders related to ACEs. Methods . We reviewed published studies to provide evidence that ACE-related methylation changes contribute to health disparities in Native Americans. This framework may be adapted to understand how ACEs may result in health disparities in other racial/ethnic groups. Findings . Here we provide evidence that links ACEs to methylation differences in genes that regulate the stress response. Psychiatric disorders are also associated with methylation differences in endocrine, immune, and neurotransmitter genes that serve to regulate the stress response and are linked to psychiatric symptoms and medical morbidity. We provide evidence linking ACEs to these epigenetic modifications, suggesting that ACEs contribute to the vulnerability for developing psychiatric disorders in Native Americans. Conclusion . Additional studies are needed to better understand how ACEs contribute to health and well-being. These studies may inform future interventions to address these serious risks and promote the health and well-being of Native Americans.

Suggested Citation

  • Teresa N. Brockie & Morgan Heinzelmann & Jessica Gill, 2013. "A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans," Nursing Research and Practice, Hindawi, vol. 2013, pages 1-9, December.
    • Handle: RePEc:hin:jnlnrp:410395
    DOI: 10.1155/2013/410395
    as

    Download full text from publisher

    File URL: http://downloads.hindawi.com/journals/NRP/2013/410395.pdf
    Download Restriction: no
    File URL: http://downloads.hindawi.com/journals/NRP/2013/410395.xml
    Download Restriction: no
    File URL: https://libkey.io/10.1155/2013/410395?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. O'Campo, P. & Xue, X. & Wang, M.-C. & Brien Caughy, M.O., 1997. "Neighborhood risk factors for low birthweight in Baltimore: A multilevel analysis," American Journal of Public Health, American Public Health Association, vol. 87(7), pages 1113-1118.
    2. Manabu Fuchikami & Shigeru Morinobu & Masahiro Segawa & Yasumasa Okamoto & Shigeto Yamawaki & Norio Ozaki & Takeshi Inoue & Ichiro Kusumi & Tsukasa Koyama & Kounosuke Tsuchiyama & Takeshi Terao, 2011. "DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-7, August.
    3. Manson, S.M. & Beals, J. & Klein, S.A. & Croy, C.D., 2005. "Social epidemiology of trauma among 2 American Indian reservation populations," American Journal of Public Health, American Public Health Association, vol. 95(5), pages 851-859.
    4. Chaix, Basile & Jouven, Xavier & Thomas, Frédérique & Leal, Cinira & Billaudeau, Nathalie & Bean, Kathy & Kestens, Yan & Jëgo, Bertrand & Pannier, Bruno & Danchin, Nicolas, 2011. "Why socially deprived populations have a faster resting heart rate: Impact of behaviour, life course anthropometry, and biology – the RECORD Cohort Study," Social Science & Medicine, Elsevier, vol. 73(10), pages 1543-1550.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yin Paradies, 2016. "Colonisation, racism and indigenous health," Journal of Population Research, Springer, vol. 33(1), pages 83-96, March.
    2. Burns, Ailish & DeAtley, Teresa & Short, Susan E., 2023. "The maternal health of American Indian and Alaska Native people: A scoping review," Social Science & Medicine, Elsevier, vol. 317(C).
    3. Jackson, Pamela & Spector, Antoinette L. & Strath, Larissa J. & Antoine, Lisa H. & Li, Peng & Goodin, Burel R. & Hidalgo, Bertha A. & Kempf, Mirjam-Colette & Gonzalez, Cesar E. & Jones, Alana C. & Fos, 2023. "Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain," Social Science & Medicine, Elsevier, vol. 331(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Shoham, David A. & Vupputuri, Suma & Kaufman, Jay S. & Kshirsagar, Abhijit V. & Diez Roux, Ana V. & Coresh, Josef & Heiss, Gerardo, 2008. "Kidney disease and the cumulative burden of life course socioeconomic conditions: The Atherosclerosis Risk in Communities (ARIC) Study," Social Science & Medicine, Elsevier, vol. 67(8), pages 1311-1320, October.
    2. Stafford, Mai & Cummins, Steven & Ellaway, Anne & Sacker, Amanda & Wiggins, Richard D. & Macintyre, Sally, 2007. "Pathways to obesity: Identifying local, modifiable determinants of physical activity and diet," Social Science & Medicine, Elsevier, vol. 65(9), pages 1882-1897, November.
    3. Ikuho Yamada & Peter Rogerson & Gyoungju Lee, 2009. "GeoSurveillance: a GIS-based system for the detection and monitoring of spatial clusters," Journal of Geographical Systems, Springer, vol. 11(2), pages 155-173, June.
    4. Catherine Paquet & Basile Chaix & Natasha J. Howard & Neil T. Coffee & Robert J. Adams & Anne W. Taylor & Frédérique Thomas & Mark Daniel, 2016. "Geographic Clustering of Cardiometabolic Risk Factors in Metropolitan Centres in France and Australia," IJERPH, MDPI, vol. 13(5), pages 1-17, May.
    5. Do, D. Phuong & Wang, Lu & Elliott, Michael R., 2013. "Investigating the relationship between neighborhood poverty and mortality risk: A marginal structural modeling approach," Social Science & Medicine, Elsevier, vol. 91(C), pages 58-66.
    6. Messer, Lynne C. & Vinikoor, Lisa C. & Laraia, Barbara A. & Kaufman, Jay S. & Eyster, Janet & Holzman, Claudia & Culhane, Jennifer & Elo, Irma & Burke, Jessica G. & O'Campo, Patricia, 2008. "Socioeconomic domains and associations with preterm birth," Social Science & Medicine, Elsevier, vol. 67(8), pages 1247-1257, October.
    7. Isaac Debache & Audrey Bergouignan & Basile Chaix & Emiel M Sneekes & Frédérique Thomas & Cédric Sueur, 2019. "Associations of Sensor-Derived Physical Behavior with Metabolic Health: A Compositional Analysis in the Record Multisensor Study," IJERPH, MDPI, vol. 16(5), pages 1-15, March.
    8. Juhn, Young J. & Sauver, Jennifer St. & Katusic, Slavica & Vargas, Delfino & Weaver, Amy & Yunginger, John, 2005. "The influence of neighborhood environment on the incidence of childhood asthma: a multilevel approach," Social Science & Medicine, Elsevier, vol. 60(11), pages 2453-2464, June.
    9. Padilla, Yolanda C. & Reichman, Nancy E., 2001. "Low birthweight: Do unwed fathers help?," Children and Youth Services Review, Elsevier, vol. 23(4-5), pages 427-452.
    10. Auger, Nathalie & Park, Alison L. & Gamache, Philippe & Pampalon, Robert & Daniel, Mark, 2012. "Weighing the contributions of material and social area deprivation to preterm birth," Social Science & Medicine, Elsevier, vol. 75(6), pages 1032-1037.
    11. Pasqualini, M. & Lanari, D. & Minelli, L. & Pieroni, L. & Salmasi, L., 2017. "Health and income inequalities in Europe: What is the role of circumstances?," Economics & Human Biology, Elsevier, vol. 26(C), pages 164-173.
    12. Kane, Robert J., 2011. "The ecology of unhealthy places: Violence, birthweight, and the importance of territoriality in structurally disadvantaged communities," Social Science & Medicine, Elsevier, vol. 73(11), pages 1585-1592.
    13. Dileepa Senajith Ediriweera & Anuradhani Kasthuriratne & Arunasalam Pathmeswaran & Nipul Kithsiri Gunawardene & Shaluka Francis Jayamanne & Kris Murray & Takuya Iwamura & David Griffith Lalloo & Hitha, 2019. "Adjusting for spatial variation when assessing individual-level risk: A case-study in the epidemiology of snake-bite in Sri Lanka," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-13, October.
    14. Shortt, S. E. D., 2004. "Making sense of social capital, health and policy," Health Policy, Elsevier, vol. 70(1), pages 11-22, October.
    15. Nazeem Muhajarine & Ronald Labonte & Allison Williams & James Randall, 2008. "Person, Perception, and Place: What Matters to Health and Quality of Life," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 85(1), pages 53-80, January.
    16. Do, D. Phuong & Finch, Brian Karl & Basurto-Davila, Ricardo & Bird, Chloe & Escarce, Jose & Lurie, Nicole, 2008. "Does place explain racial health disparities? Quantifying the contribution of residential context to the Black/white health gap in the United States," Social Science & Medicine, Elsevier, vol. 67(8), pages 1258-1268, October.
    17. Ncube, Collette N. & Enquobahrie, Daniel A. & Albert, Steven M. & Herrick, Amy L. & Burke, Jessica G., 2016. "Association of neighborhood context with offspring risk of preterm birth and low birthweight: A systematic review and meta-analysis of population-based studies," Social Science & Medicine, Elsevier, vol. 153(C), pages 156-164.
    18. Gbenga A Kayode & Mary Amoakoh-Coleman & Irene Akua Agyepong & Evelyn Ansah & Diederick E Grobbee & Kerstin Klipstein-Grobusch, 2014. "Contextual Risk Factors for Low Birth Weight: A Multilevel Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
    19. Levi J Wolf & Elijah Knaap & Sergio Rey, 2021. "Geosilhouettes: Geographical measures of cluster fit," Environment and Planning B, , vol. 48(3), pages 521-539, March.
    20. Anastario, Mike & FireMoon, Paula & Rink, Elizabeth, 2020. "Sexual risk behaviors and the legacy of colonial violence among Northern plains American Indian youth: A mixed methods exploratory study," Social Science & Medicine, Elsevier, vol. 258(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hin:jnlnrp:410395. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Mohamed Abdelhakeem (email available below). General contact details of provider: https://www.hindawi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.