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Exploring the Stochastic Host-Pathogen Tuberculosis Model with Adaptive Immune Response

Author

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  • S. P. Rajasekar
  • M. Pitchaimani
  • Quanxin Zhu
  • Kaibo Shi

Abstract

In this literature, we probe a stochastic host-pathogen tuberculosis model with the adaptive immune response of four states of epidemiological classification: Mycobacterium tuberculosis , uninfected macrophages, infected macrophages, and immune response CD4+ T cells. This model is pertinent to the latent stage of tuberculosis infection and active tuberculosis-infected individuals. The stochastic host-pathogen tuberculosis model in pathology is constituted based on the environmental influence on the Mycobacterium tuberculosis and macrophage population, elucidated by stochastic perturbations, and it is proportional to each state. We evince the existence and a unique global positive solution of a stochastic tuberculosis model. We attain sufficient conditions for the extinction of the tubercle bacillus. Moreover, we acquire the existence of the stationary distribution of the positive solutions by the Lyapunov function method. Eventually, numerical simulations validate analytical findings and the dynamics of the stochastic TB model.

Suggested Citation

  • S. P. Rajasekar & M. Pitchaimani & Quanxin Zhu & Kaibo Shi, 2021. "Exploring the Stochastic Host-Pathogen Tuberculosis Model with Adaptive Immune Response," Mathematical Problems in Engineering, Hindawi, vol. 2021, pages 1-23, June.
    • Handle: RePEc:hin:jnlmpe:8879538
    DOI: 10.1155/2021/8879538
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    Cited by:

    1. Laaribi, Aziz & Boukanjime, Brahim & El Khalifi, Mohamed & Bouggar, Driss & El Fatini, Mohamed, 2023. "A generalized stochastic SIRS epidemic model incorporating mean-reverting Ornstein–Uhlenbeck process," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 615(C).
    2. Sabbar, Yassine & Kiouach, Driss & Rajasekar, S.P. & El-idrissi, Salim El Azami, 2022. "The influence of quadratic Lévy noise on the dynamic of an SIC contagious illness model: New framework, critical comparison and an application to COVID-19 (SARS-CoV-2) case," Chaos, Solitons & Fractals, Elsevier, vol. 159(C).
    3. Elaiw, A.M. & Alsaedi, A.J. & Hobiny, A.D. & Aly, S., 2023. "Stability of a delayed SARS-CoV-2 reactivation model with logistic growth and adaptive immune response," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 616(C).
    4. Shi, Zhenfeng & Jiang, Daqing & Zhang, Xinhong & Alsaedi, Ahmed, 2022. "A stochastic SEIRS rabies model with population dispersal: Stationary distribution and probability density function," Applied Mathematics and Computation, Elsevier, vol. 427(C).

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