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DESnets: A Graphical Representation for Discrete Event Simulation and Cost-Effectiveness Analysis

Author

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  • Carmen María Yago

    (Department of Artificial Intelligence, Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain)

  • Francisco Javier Díez

    (Department of Artificial Intelligence, Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain)

Abstract

Cost-effectiveness analysis (CEA) is used increasingly in medicine to determine whether the health benefit of an intervention is worth the economic cost. Discrete event simulation (DES) is playing an increasing role in CEA thanks to several advantages, such as the possibility of modeling time and heterogeneous populations. It is usually implemented with general-purpose programming languages or commercial software packages. To our knowledge, no artificial intelligence technique has been applied to DES for CEA. Our objective is to develop a graphical representation, an algorithm, and a software tool that allows non-programmers to easily build models and perform CEA. We present DESnets (discrete event simulation networks) as a new type of probabilistic graphical model inspired by probabilistic influence diagrams, an algorithm for evaluating and an implementation as an OpenMarkov plug-in. DESnets are compared qualitatively and empirically with six alternative tools using as a running example a model about osteoporosis by the British National Institute for Health and Care Excellence (NICE). In our experiments, the implementation of DESnets allowed the building of a typical DES model declaratively. Its evaluation process ranked among the most efficient. DESnets compare favorably with alternative tools in terms of ease of use, expressive power, transparency, and computational efficiency.

Suggested Citation

  • Carmen María Yago & Francisco Javier Díez, 2023. "DESnets: A Graphical Representation for Discrete Event Simulation and Cost-Effectiveness Analysis," Mathematics, MDPI, vol. 11(7), pages 1-24, March.
    • Handle: RePEc:gam:jmathe:v:11:y:2023:i:7:p:1602-:d:1107775
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    References listed on IDEAS

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    1. Matthew J. Glover & Edmund Jones & Katya L. Masconi & Michael J. Sweeting & Simon G. Thompson, 2018. "Discrete Event Simulation for Decision Modeling in Health Care: Lessons from Abdominal Aortic Aneurysm Screening," Medical Decision Making, , vol. 38(4), pages 439-451, May.
    2. Jonathan Karnon & Hossein Haji Ali Afzali, 2014. "When to Use Discrete Event Simulation (DES) for the Economic Evaluation of Health Technologies? A Review and Critique of the Costs and Benefits of DES," PharmacoEconomics, Springer, vol. 32(6), pages 547-558, June.
    3. Jackson, Christopher, 2016. "flexsurv: A Platform for Parametric Survival Modeling in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 70(i08).
    4. Becky Pennington & Alex Filby & Lesley Owen & Matthew Taylor, 2018. "Smoking Cessation: A Comparison of Two Model Structures," PharmacoEconomics, Springer, vol. 36(9), pages 1101-1112, September.
    5. Fernando Alarid-Escudero & Eline M. Krijkamp & Petros Pechlivanoglou & Hawre Jalal & Szu-Yu Zoe Kao & Alan Yang & Eva A. Enns, 2019. "A Need for Change! A Coding Framework for Improving Transparency in Decision Modeling," PharmacoEconomics, Springer, vol. 37(11), pages 1329-1339, November.
    6. Syed Salleh & Praveen Thokala & Alan Brennan & Ruby Hughes & Simon Dixon, 2017. "Discrete Event Simulation-Based Resource Modelling in Health Technology Assessment," PharmacoEconomics, Springer, vol. 35(10), pages 989-1006, October.
    7. Alan Brennan & Stephen E. Chick & Ruth Davies, 2006. "A taxonomy of model structures for economic evaluation of health technologies," Health Economics, John Wiley & Sons, Ltd., vol. 15(12), pages 1295-1310, December.
    8. Jörgen Möller & Sarah Davis & Matt Stevenson & J. Jaime Caro, 2017. "Validation of a DICE Simulation Against a Discrete Event Simulation Implemented Entirely in Code," PharmacoEconomics, Springer, vol. 35(10), pages 1103-1109, October.
    9. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
    10. John Graves & Shawn Garbett & Zilu Zhou & Jonathan S. Schildcrout & Josh Peterson, 2021. "Comparison of Decision Modeling Approaches for Health Technology and Policy Evaluation," Medical Decision Making, , vol. 41(4), pages 453-464, May.
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