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Profile and Non-Profile MM Modeling of Cluster Failure Time and Analysis of ADNI Data

Author

Listed:
  • Xifen Huang

    (School of Mathematics, Yunnan Normal University, Kunming 650092, China)

  • Jinfeng Xu

    (School of Mathematics, Yunnan Normal University, Kunming 650092, China)

  • Yunpeng Zhou

    (Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam, Hong Kong, China)

Abstract

Motivated by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, the objective of integration of important biomarkers for the early detection of Mild Cognitive Impairment (MCI) to Alzheimer’s disease (AD) as a therapeutic intervention is most likely to be beneficial in the early stages of disease progression. Developing predictors for MCI to AD comes down to genotype variables such that the dimension of predictors increases as the sample becomes large. Thus, we consider the sparsity concept of coefficients in a high-dimensional regression model with clustered failure time data such as ADNI, which enables enhancing predictive performances and facilitates the model’s interpretability. In this study, we propose two MM algorithms (profile and non-profile) for the shared frailty survival model firstly and then extend the two proposed MM algorithms to regularized estimation in sparse high-dimensional regression model. The convergence properties of our proposed estimators are also established. Furthermore simulation studies and analysis of ADNI data are illustrated by our proposed methods.

Suggested Citation

  • Xifen Huang & Jinfeng Xu & Yunpeng Zhou, 2022. "Profile and Non-Profile MM Modeling of Cluster Failure Time and Analysis of ADNI Data," Mathematics, MDPI, vol. 10(4), pages 1-21, February.
    • Handle: RePEc:gam:jmathe:v:10:y:2022:i:4:p:538-:d:745324
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    References listed on IDEAS

    as
    1. Hunter D.R. & Lange K., 2004. "A Tutorial on MM Algorithms," The American Statistician, American Statistical Association, vol. 58, pages 30-37, February.
    2. Ravi Varadhan & Christophe Roland, 2008. "Simple and Globally Convergent Methods for Accelerating the Convergence of Any EM Algorithm," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 35(2), pages 335-353, June.
    3. Donglin Zeng & Qingxia Chen & Joseph G. Ibrahim, 2009. "Gamma frailty transformation models for multivariate survival times," Biometrika, Biometrika Trust, vol. 96(2), pages 277-291.
    4. Fan J. & Li R., 2001. "Variable Selection via Nonconcave Penalized Likelihood and its Oracle Properties," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 1348-1360, December.
    5. Dehan Kong & Joseph G. Ibrahim & Eunjee Lee & Hongtu Zhu, 2018. "FLCRM: Functional linear cox regression model," Biometrics, The International Biometric Society, vol. 74(1), pages 109-117, March.
    6. Hui Zou & Trevor Hastie, 2005. "Addendum: Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(5), pages 768-768, November.
    7. Hui Zou & Trevor Hastie, 2005. "Regularization and variable selection via the elastic net," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 67(2), pages 301-320, April.
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