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Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City

Author

Listed:
  • Kyung Hwa Jung

    (Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W. 168 St. New York, NY 10032, USA)

  • Beizhan Yan

    (Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, NY 10964, USA)

  • Steven N. Chillrud

    (Lamont-Doherty Earth Observatory, Columbia University, 61 Rt, 9W Palisades, NY 10964, USA)

  • Frederica P. Perera

    (Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA)

  • Robin Whyatt

    (Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA)

  • David Camann

    (Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78228, USA)

  • Patrick L. Kinney

    (Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA)

  • Rachel L. Miller

    (Division of Pulmonary, Allergy and Critical Care of Medicine, College of Physicians and Surgeons, Columbia University, PH8E, 630 W. 168 St. New York, NY 10032, USA
    Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 60 Haven Ave., B-1 New York, NY 10032, USA)

Abstract

The application of benzo(a)pyrene (BaP)-toxic equivalent factor to polycyclic aromatic hydrocarbons (PAH) concentrations can provide a more accurate risk assessment from environmental exposure to PAH. We hypothesized that BaP-equivalent toxicity determined following residential air monitoring among young urban children may vary by season. Residential indoor and outdoor air levels of PAH measured over two-weeks in a cohort of 5–6 year old children (n = 260) in New York City were normalized to the cancer and mutagen potency equivalent factor of BaP (BaP = 1). Data are presented as carcinogenic equivalents (BaP-TEQ) and mutagenic equivalents (BaP-MEQ) for the sum of 8 PAH (∑ 8 PAH; MW ³ 228) and individual PAH and compared across heating versus nonheating seasons. Results show that heating compared to nonheating season was associated significantly with higher (BaP-TEQ) ∑8PAH and (BaP-MEQ) ∑8PAH both indoors and outdoors (p ∑8PAH and (BaP-MEQ) ∑8PAH were significantly higher than the corresponding indoor measures during the heating season (p

Suggested Citation

  • Kyung Hwa Jung & Beizhan Yan & Steven N. Chillrud & Frederica P. Perera & Robin Whyatt & David Camann & Patrick L. Kinney & Rachel L. Miller, 2010. "Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City," IJERPH, MDPI, vol. 7(5), pages 1-12, April.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:5:p:1889-1900:d:8099
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    Citations

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    Cited by:

    1. Gordana Pehnec & Ivana Jakovljević, 2018. "Carcinogenic Potency of Airborne Polycyclic Aromatic Hydrocarbons in Relation to the Particle Fraction Size," IJERPH, MDPI, vol. 15(11), pages 1-25, November.
    2. Jenni A. Shearston & A. Mychal Johnson & Arce Domingo-Relloso & Marianthi-Anna Kioumourtzoglou & Diana Hernández & James Ross & Steven N. Chillrud & Markus Hilpert, 2020. "Opening a Large Delivery Service Warehouse in the South Bronx: Impacts on Traffic, Air Pollution, and Noise," IJERPH, MDPI, vol. 17(9), pages 1-19, May.
    3. Vítězslav Jiřík & Ladislav Tomášek & Ivana Fojtíková & Tomáš Janoš & Markéta Stanovská & Pavlína Guňková & Andrea Dalecká & Adéla Vrtková & Radim J. Šrám, 2021. "Lifetime Carcinogenic Risk Proportions from Inhalation Exposures in Industrial and Non-Industrial Regions," IJERPH, MDPI, vol. 18(24), pages 1-17, December.
    4. Yan Wang & Hao Zhang & Xuan Zhang & Pengchu Bai & Andrey Neroda & Vassily F. Mishukov & Lulu Zhang & Kazuichi Hayakawa & Seiya Nagao & Ning Tang, 2022. "PM-Bound Polycyclic Aromatic Hydrocarbons and Nitro-Polycyclic Aromatic Hydrocarbons in the Ambient Air of Vladivostok: Seasonal Variation, Sources, Health Risk Assessment and Long-Term Variability," IJERPH, MDPI, vol. 19(5), pages 1-13, March.

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