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Cellular and Mitochondrial Effects of Alcohol Consumption

Author

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  • Salvador Manzo-Avalos

    (Instituto de Investigaciones Quimico-Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Edificio B-3. C.U., 58030 Morelia, Michoacan, Mexico)

  • Alfredo Saavedra-Molina

    (Instituto de Investigaciones Quimico-Biologicas, Universidad Michoacana de San Nicolas de Hidalgo, Edificio B-3. C.U., 58030 Morelia, Michoacan, Mexico)

Abstract

Alcohol dependence is correlated with a wide spectrum of medical, psychological, behavioral, and social problems. Acute alcohol abuse causes damage to and functional impairment of several organs affecting protein, carbohydrate, and fat metabolism. Mitochondria participate with the conversion of acetaldehyde into acetate and the generation of increased amounts of NADH. Prenatal exposure to ethanol during fetal development induces a wide spectrum of adverse effects in offspring, such as neurologic abnormalities and pre- and post-natal growth retardation. Antioxidant effects have been described due to that alcoholic beverages contain different compounds, such as polyphenols as well as resveratrol. This review analyzes diverse topics on the alcohol consumption effects in several human organs and demonstrates the direct participation of mitochondria as potential target of compounds that can be used to prevent therapies for alcohol abusers.

Suggested Citation

  • Salvador Manzo-Avalos & Alfredo Saavedra-Molina, 2010. "Cellular and Mitochondrial Effects of Alcohol Consumption," IJERPH, MDPI, vol. 7(12), pages 1-24, December.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:12:p:4281-4304:d:10652
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    References listed on IDEAS

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    1. Konrad T. Howitz & Kevin J. Bitterman & Haim Y. Cohen & Dudley W. Lamming & Siva Lavu & Jason G. Wood & Robert E. Zipkin & Phuong Chung & Anne Kisielewski & Li-Li Zhang & Brandy Scherer & David A. Sin, 2003. "Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan," Nature, Nature, vol. 425(6954), pages 191-196, September.
    2. Alejandra Miranda-Mendez & Alejandro Lugo-Baruqui & Juan Armendariz-Borunda, 2010. "Molecular Basis and Current Treatment for Alcoholic Liver Disease," IJERPH, MDPI, vol. 7(5), pages 1-17, April.
    3. Rui Guo & Jun Ren, 2010. "Alcohol and Acetaldehyde in Public Health: From Marvel to Menace," IJERPH, MDPI, vol. 7(4), pages 1-17, March.
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    Citations

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    Cited by:

    1. Constanza Morén & Sandra Hernández & Mariona Guitart-Mampel & Glòria Garrabou, 2014. "Mitochondrial Toxicity in Human Pregnancy: An Update on Clinical and Experimental Approaches in the Last 10 Years," IJERPH, MDPI, vol. 11(9), pages 1-22, September.
    2. Anna N. Bukiya, 2019. "Fetal Cerebral Artery Mitochondrion as Target of Prenatal Alcohol Exposure," IJERPH, MDPI, vol. 16(9), pages 1-16, May.
    3. Hee-Young Ahn & Young-Su Cho, 2020. "An Animal Study to Compare Hepatoprotective Effects Between Fermented Rice Bran and Fermented Rice Germ and Soybean in a Sprague-Dawley Rat Model of Alcohol-Induced Hepatic Injury," J, MDPI, vol. 3(1), pages 1-13, February.
    4. Donatello Carrino & Jacopo Junio Valerio Branca & Matteo Becatti & Ferdinando Paternostro & Gabriele Morucci & Massimo Gulisano & Lorenzo Di Cesare Mannelli & Alessandra Pacini, 2021. "Alcohol-Induced Blood-Brain Barrier Impairment: An In Vitro Study," IJERPH, MDPI, vol. 18(5), pages 1-14, March.

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