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Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

Author

Listed:
  • Rui Guo

    (Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, College of Health Sciences, WY 82071, USA)

  • Jun Ren

    (Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, College of Health Sciences, WY 82071, USA)

Abstract

Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and social problems. In addition, genetic susceptibility to the effect of alcohol on cancer and coronary heart disease differs across the population. A number of mechanisms including direct the toxicity of ethanol, its metabolites [e.g., acetaldehyde and fatty acid ethyl esters (FAEEs)] and oxidative stress may mediate alcoholic complications. Acetaldehyde, the primary metabolic product of ethanol, is an important candidate toxin in developing alcoholic diseases. Meanwhile, free radicals produced during ethanol metabolism and FAEEs are also important triggers for alcoholic damages.

Suggested Citation

  • Rui Guo & Jun Ren, 2010. "Alcohol and Acetaldehyde in Public Health: From Marvel to Menace," IJERPH, MDPI, vol. 7(4), pages 1-17, March.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1285-1301:d:7632
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    References listed on IDEAS

    as
    1. Lipton, R.I., 1994. "The effect of moderate alcohol use on the relationship between stress and depression," American Journal of Public Health, American Public Health Association, vol. 84(12), pages 1913-1917.
    2. Cohen, S. & Tyrrell, D.A.J. & Russell, M.A.H. & Jarvis, M.J. & Smith, A.P., 1993. "Smoking, alcohol consumption, and susceptibility to the common cold," American Journal of Public Health, American Public Health Association, vol. 83(9), pages 1277-1283.
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    Cited by:

    1. Salvador Manzo-Avalos & Alfredo Saavedra-Molina, 2010. "Cellular and Mitochondrial Effects of Alcohol Consumption," IJERPH, MDPI, vol. 7(12), pages 1-24, December.

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