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Performance in the Six-Minute Walking Test Does Not Discriminate Excessive Erythrocytosis Patients in a Severe Hypoxic Environment

Author

Listed:
  • Rossela Alejandra Rojas-Chambilla

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Kely Melina Vilca-Coaquira

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Jeancarlo Tejada-Flores

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Henry Oscar Tintaya-Ramos

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Mariela Mercedes Quispe-Trujillo

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Ángel Gabriel Calisaya-Huacasi

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Solanyela Anny Quispe-Humpiri

    (Facultad de Medicina Humana, Universidad Nacional del Altiplano, Puno 21000, Peru
    Asociación Científica de Estudiantes de Medicina (ACEM), Puno 21000, Peru)

  • Yony Martin Pino-Vanegas

    (Escuela Profesional de Educación Física, Facultad de Ciencias de la Educación, Universidad Nacional del Altiplano, Puno 21000, Peru)

  • Alberto Alcibiades Salazar-Granara

    (Centro de Investigación en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima 15024, Peru)

  • Ana Lucía Tácuna-Calderón

    (Centro de Investigación en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima 15024, Peru)

  • Nancy Mónica García-Bedoya

    (Centro de Investigación en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima 15024, Peru)

  • Moua Yang

    (Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Bloodworks Northwest Research Institute, Seattle, WA 98102, USA
    Division of Hematology and Oncology, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98102, USA)

  • Ginés Viscor

    (Secció de Fisiologia, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, E-08028 Barcelona, Spain)

  • Iván Hancco-Zirena

    (Centro de Investigación en Medicina de Altura (CIMA), Facultad de Medicina Humana, Universidad de San Martín de Porres, Lima 15024, Peru
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA)

Abstract

Background: Chronic exposure to severe hypoxia causes an increase in hematocrit (Hct) and hemoglobin concentration ([Hb]), which can lead to excessive erythrocytosis (EE) and impact physical performance. This work aims to determine the differences in the six-minute walking test (6MWT) between EE and healthy subjects residing at more than 5000 m. Methods: A prospective, cross-sectional study was performed on 71 men (36 healthy and 25 suffering from EE) living in La Rinconada, Peru (5100 m). Basal levels of [Hb] and Hct were obtained. All the subjects performed the 6MWT, and distance reached, vital signs, dyspnea, and fatigue (Borg scale) at the end of the test were recorded. Results: The average [Hb] and Hct levels in the control group were 18.7 ± 1.2 g/dL and 60.4 ± 7.1%, respectively, contrasting with EE subjects, who showed 23.4 ± 1.6 g/dL and 73.6 ± 5.9% ( p < 0.001). However, no statistically significant differences were observed in BMI or other anthropometric parameters. At the end of the 6MWT, the distance traveled and vital constants were similar between both groups, except for arterial oxygen saturation, which was consistently lower in subjects with EE throughout the test. Conclusion: EE does not significantly affect 6MWT performance at high altitudes, nor the hemodynamic control during moderate aerobic exercise of subjects who live permanently in a severely hypoxic environment.

Suggested Citation

  • Rossela Alejandra Rojas-Chambilla & Kely Melina Vilca-Coaquira & Jeancarlo Tejada-Flores & Henry Oscar Tintaya-Ramos & Mariela Mercedes Quispe-Trujillo & Ángel Gabriel Calisaya-Huacasi & Solanyela Ann, 2024. "Performance in the Six-Minute Walking Test Does Not Discriminate Excessive Erythrocytosis Patients in a Severe Hypoxic Environment," IJERPH, MDPI, vol. 21(9), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:9:p:1119-:d:1463753
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    References listed on IDEAS

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    1. Akylbek Sydykov & Argen Mamazhakypov & Abdirashit Maripov & Djuro Kosanovic & Norbert Weissmann & Hossein Ardeschir Ghofrani & Akpay Sh. Sarybaev & Ralph Theo Schermuly, 2021. "Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders," IJERPH, MDPI, vol. 18(4), pages 1-33, February.
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