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MMP-8 in Periodontal Sites of Postpartum and without-Any-Pregnancy Women

Author

Listed:
  • Karyne Martins Lima

    (Postgraduate Program in Dentistry, Federal University of Maranhão, São Luís CEP 65080-805, Brazil)

  • Keiko Aramaki Abreu Calado

    (Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís CEP 65080-805, Brazil)

  • Adriana de Fátima Vasconcelos Pereira

    (Teacher of the Department of Dentistry II, Federal University of Maranhão, São Luís CEP 65080-805, Brazil)

  • Mayara Cristina Pinto da Silva

    (Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís CEP 65080-805, Brazil)

  • Fernanda Ferreira Lopes

    (Postgraduate Program in Dentistry, Federal University of Maranhão, São Luís CEP 65080-805, Brazil
    Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís CEP 65080-805, Brazil
    Teacher of the Department of Dentistry II, Federal University of Maranhão, São Luís CEP 65080-805, Brazil)

Abstract

The hypothesis that physiological changes in women can affect periodontal tissues is the subject of this study, and inflammatory markers such as matrix metalloproteinase-8 can measure susceptibility to inflammation. The study aimed to analyze MMP-8 levels in periodontal sites of postpartum women and women without a history of pregnancy, comparing health parameters and periodontal disease. This is a case–control study with 40 participants, 20 cases (women in the postpartum period) and 20 controls (women without any pregnancy), who underwent clinical periodontal examination and the collection of crevicular gingival fluid. The ELISA test was used to detect MMP-8 levels. Postpartum women had worse periodontal parameters, such as bleeding index on probing, number of sites with CAL ≥ 3, and fewer teeth present. In the group of women without a history of pregnancy, a significantly lower MMP-8 level was observed in healthy sites and a higher one was observed in periodontal pockets ( p < 0.01). In contrast, in postpartum women, MMP-8 levels were elevated in both healthy sites and periodontal pockets ( p > 0.01). The MMP-8 levels in gingival fluid appear to be related to periodontal clinical parameters and may be a possible marker of enzymatic changes involved in periodontal tissue destruction in postpartum women.

Suggested Citation

  • Karyne Martins Lima & Keiko Aramaki Abreu Calado & Adriana de Fátima Vasconcelos Pereira & Mayara Cristina Pinto da Silva & Fernanda Ferreira Lopes, 2024. "MMP-8 in Periodontal Sites of Postpartum and without-Any-Pregnancy Women," IJERPH, MDPI, vol. 21(6), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:6:p:739-:d:1409809
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    References listed on IDEAS

    as
    1. Sarhang Sarwat Gul & Faraedon Mostafa Zardawi & Ali Abbas Abdulkareem & Muhammad Saad Shaikh & Natheer Hashim Al-Rawi & Muhammad Sohail Zafar, 2022. "Efficacy of MMP-8 Level in Gingival Crevicular Fluid to Predict the Outcome of Nonsurgical Periodontal Treatment: A Systematic Review," IJERPH, MDPI, vol. 19(5), pages 1-14, March.
    2. Ji-Youn Kim & Han-Na Kim, 2020. "Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(1), pages 1-16, December.
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