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Efficacy of MMP-8 Level in Gingival Crevicular Fluid to Predict the Outcome of Nonsurgical Periodontal Treatment: A Systematic Review

Author

Listed:
  • Sarhang Sarwat Gul

    (Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq)

  • Faraedon Mostafa Zardawi

    (Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq)

  • Ali Abbas Abdulkareem

    (Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad 10011, Iraq)

  • Muhammad Saad Shaikh

    (Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi 75510, Pakistan)

  • Natheer Hashim Al-Rawi

    (Department of Oral & Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates)

  • Muhammad Sohail Zafar

    (Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madina, Al Munawwarra 41311, Saudi Arabia
    Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad 44000, Pakistan)

Abstract

Purpose: To explore whether baseline matrix metalloproteinase (MMP)-8 level in gingival crevicular fluid (GCF) (exposure) can predict the outcome (reduction in probing pocket depth (PPD) (outcome)) of nonsurgical periodontal therapy (NSPT) (manual or ultrasonic or both) in patients with periodontitis (population/problem) after 3 months. Methods: Six databases (PubMed, Cochrane library, ProQuest, Ovid, Scopus, EBSCO) were searched for relevant articles published until 30 July 2021. Retrieved articles were passed through a three-phase filtration process on the basis of the eligibility criteria. The primary outcome was the change in PPD after 3 months. Quality of the selected articles was assessed using Cochrane Risk of Bias tool (RoB2) and Risk of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tools. Results: From 1306 articles, five were selected for analysis. The results showed high variations in the level of GCF MMP-8 level at baseline. The average amount of reduction in PPD was 1.20 and 2.30 mm for pockets with initial depth of 4–6 mm and >6 mm, respectively. Conclusion: On the basis of available evidence, it was not possible to reach a consensus on the ability of baseline GCF MMP-8 to forecast the outcome of NSPT. This could have been due to variation in clinical and laboratory techniques used. However, consistency in mean PPD reduction after 3 months was shown.

Suggested Citation

  • Sarhang Sarwat Gul & Faraedon Mostafa Zardawi & Ali Abbas Abdulkareem & Muhammad Saad Shaikh & Natheer Hashim Al-Rawi & Muhammad Sohail Zafar, 2022. "Efficacy of MMP-8 Level in Gingival Crevicular Fluid to Predict the Outcome of Nonsurgical Periodontal Treatment: A Systematic Review," IJERPH, MDPI, vol. 19(5), pages 1-14, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:3131-:d:765723
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    References listed on IDEAS

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    1. Gianna Maria Nardi & Francesca Cesarano & Giulio Papa & Lorella Chiavistelli & Roman Ardan & Maciej Jedlinski & Marta Mazur & Roberta Grassi & Felice Roberto Grassi, 2020. "Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial," IJERPH, MDPI, vol. 17(18), pages 1-10, September.
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    Cited by:

    1. Karyne Martins Lima & Keiko Aramaki Abreu Calado & Adriana de Fátima Vasconcelos Pereira & Mayara Cristina Pinto da Silva & Fernanda Ferreira Lopes, 2024. "MMP-8 in Periodontal Sites of Postpartum and without-Any-Pregnancy Women," IJERPH, MDPI, vol. 21(6), pages 1-11, June.

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