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Atrial Fibrillation and Other Cardiovascular Factors and the Risk of Dementia: An Italian Case–Control Study

Author

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  • Riccardo Mazzoli

    (Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41225 Modena, Italy)

  • Annalisa Chiari

    (Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy)

  • Marco Vitolo

    (Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, 41124 Modena, Italy)

  • Caterina Garuti

    (Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41225 Modena, Italy
    Post Graduate School of Pediatrics, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, 41124 Modena, Italy)

  • Giorgia Adani

    (Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41225 Modena, Italy)

  • Giulia Vinceti

    (Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy)

  • Giovanna Zamboni

    (Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy
    Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy)

  • Manuela Tondelli

    (Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy
    Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy)

  • Chiara Galli

    (Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy
    Primary Care Department, Modena Local Health Authority, 41124 Modena, Italy)

  • Manuela Costa

    (Neurology Unit of Carpi Hospital, Modena Local Health Authority, 41012 Carpi, Italy)

  • Simone Salemme

    (Neurology Unit, Baggiovara Hospital, AOU Modena, 41126 Modena, Italy
    Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
    School of Advanced Studies, University of Camerino, 62032 Camerino, Italy)

  • Giuseppe Boriani

    (Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, 41124 Modena, Italy)

  • Marco Vinceti

    (Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41225 Modena, Italy
    Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA)

  • Tommaso Filippini

    (Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41225 Modena, Italy
    School of Public Health, University of California Berkeley, Berkeley, CA 94704, USA)

Abstract

Dementia is a major neurologic syndrome characterized by severe cognitive decline, and it has a detrimental impact on overall physical health, leading to conditions such as frailty, changes in gait, and fall risk. Depending on whether symptoms occur before or after the age of 65, it can be classified as early-onset (EOD) or late-onset (LOD) dementia. The present study is aimed at investigating the role of cardiovascular factors on EOD and LOD risk in an Italian population. Using a case–control study design, EOD and LOD cases were recruited at the Modena Cognitive Neurology Centers in 2016–2019. Controls were recruited among caregivers of all the dementia cases. Information about their demographics, lifestyles, and medical history were collected through a tailored questionnaire. We used the odds ratio (OR) and 95% confidence interval (CI) to estimate the EOD and LOD risk associated with the investigated factors after adjusting for potential confounders. Of the final 146 participants, 58 were diagnosed with EOD, 34 with LOD, and 54 were controls. According to their medical history, atrial fibrillation was associated with increased disease risk (ORs 1.90; 95% CI 0.32–11.28, and 3.64; 95% CI 0.32–41.39 for EOD and LOD, respectively). Dyslipidemia and diabetes showed a positive association with EOD, while the association was negative for LOD. We could not evaluate the association between myocardial infarction and EOD, while increased risk was observed for LOD. No clear association emerged for carotid artery stenosis or valvular heart disease. In this study, despite the limited number of exposed subjects and the high imprecision of the estimates, we found positive associations between cardiovascular disease, particularly dyslipidemia, diabetes, and atrial fibrillation, and EOD.

Suggested Citation

  • Riccardo Mazzoli & Annalisa Chiari & Marco Vitolo & Caterina Garuti & Giorgia Adani & Giulia Vinceti & Giovanna Zamboni & Manuela Tondelli & Chiara Galli & Manuela Costa & Simone Salemme & Giuseppe Bo, 2024. "Atrial Fibrillation and Other Cardiovascular Factors and the Risk of Dementia: An Italian Case–Control Study," IJERPH, MDPI, vol. 21(6), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:6:p:688-:d:1403212
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    References listed on IDEAS

    as
    1. Giorgia Adani & Tommaso Filippini & Caterina Garuti & Marcella Malavolti & Giulia Vinceti & Giovanna Zamboni & Manuela Tondelli & Chiara Galli & Manuela Costa & Marco Vinceti & Annalisa Chiari, 2020. "Environmental Risk Factors for Early-Onset Alzheimer’s Dementia and Frontotemporal Dementia: A Case-Control Study in Northern Italy," IJERPH, MDPI, vol. 17(21), pages 1-18, October.
    2. Kay Deckers & Syenna H J Schievink & Maria M F Rodriquez & Robert J van Oostenbrugge & Martin P J van Boxtel & Frans R J Verhey & Sebastian Köhler, 2017. "Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-15, September.
    3. Tommaso Filippini & Marina Tesauro & Maria Fiore & Carlotta Malagoli & Michela Consonni & Federica Violi & Laura Iacuzio & Elisa Arcolin & Gea Oliveri Conti & Antonio Cristaldi & Pietro Zuccarello & E, 2020. "Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study," IJERPH, MDPI, vol. 17(8), pages 1-13, April.
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