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Innovative In Vitro Strategy for Assessing Aluminum Bioavailability in Oral Care Cosmetics

Author

Listed:
  • Giorgia Allaria

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Giulia De Negri Atanasio

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Tommaso Filippini

    (CREAGEN—Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
    School of Public Health, University of California Berkeley, Berkeley, CA 94704, USA)

  • Federica Robino

    (Angel Consulting Via San Senatore 14, 20122 Milano, Italy)

  • Lorenzo Dondero

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
    MICAMO S.R.L, 16121 Genoa, Italy)

  • Francesco Soggia

    (Department of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, 16146 Genoa, Italy)

  • Francesca Rispo

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Francesca Tardanico

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Sara Ferrando

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Stefano Aicardi

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Ilaria Demori

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

  • Jan Markus

    (MatTek In Vitro Life Science Laboratories, 82105 Bratislava, Slovakia)

  • Katia Cortese

    (Cellular Electron Microscopy Laboratory, Department of Experimental Medicine (DIMES), Human Anatomy, University of Genoa, 16132 Genoa, Italy)

  • Matteo Zanotti-Russo

    (Angel Consulting Via San Senatore 14, 20122 Milano, Italy)

  • Elena Grasselli

    (Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy)

Abstract

Aluminum is an element found in nature and in cosmetic products. It can interfere with the metabolism of other cations, thus inducing gastrointestinal disorder. In cosmetics, aluminum is used in antiperspirants, lipsticks, and toothpastes. The aim of this work is to investigate aluminum bioavailability after accidental oral ingestion derived from the use of a toothpaste containing a greater amount of aluminum hydroxide than advised by the Scientific Committee on Consumer Safety (SCCS). To simulate in vitro toothpaste accidental ingestion, the INFOGEST model was employed, and the amount of aluminum was measured through the ICP-AES analysis. Tissue barrier integrity was analyzed by measuring transepithelial electric resistance, and the tissue architecture was checked through light microscopy. The margin of safety was also calculated. Overall, our results indicate that the acute exposure to aluminum accidentally ingested from toothpastes is safe for the final user, even in amounts higher than SCCS indications.

Suggested Citation

  • Giorgia Allaria & Giulia De Negri Atanasio & Tommaso Filippini & Federica Robino & Lorenzo Dondero & Francesco Soggia & Francesca Rispo & Francesca Tardanico & Sara Ferrando & Stefano Aicardi & Ilaria, 2022. "Innovative In Vitro Strategy for Assessing Aluminum Bioavailability in Oral Care Cosmetics," IJERPH, MDPI, vol. 19(15), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9362-:d:876652
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    References listed on IDEAS

    as
    1. Giorgia Adani & Tommaso Filippini & Caterina Garuti & Marcella Malavolti & Giulia Vinceti & Giovanna Zamboni & Manuela Tondelli & Chiara Galli & Manuela Costa & Marco Vinceti & Annalisa Chiari, 2020. "Environmental Risk Factors for Early-Onset Alzheimer’s Dementia and Frontotemporal Dementia: A Case-Control Study in Northern Italy," IJERPH, MDPI, vol. 17(21), pages 1-18, October.
    2. Shu-Han You & Szu-Chieh Chen & Chin-Hsin Lin & Yen-Chu Chen, 2021. "Probabilistic Risk Analysis to Assess Dietary Exposure to Aluminum in the Taiwanese Population," IJERPH, MDPI, vol. 18(3), pages 1-17, January.
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