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Suicide Mortality Risk among Patients with Lung Cancer—A Systematic Review and Meta-Analysis

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  • Luisa Hofmann

    (Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany
    Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany)

  • Michael Heinrich

    (Faculty of Medicine, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany)

  • Hansjörg Baurecht

    (Department of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany)

  • Berthold Langguth

    (Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany)

  • Peter M. Kreuzer

    (Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053 Regensburg, Germany)

  • Helge Knüttel

    (University Library, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany)

  • Michael F. Leitzmann

    (Department of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany)

  • Corinna Seliger

    (Department of Neurology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany)

Abstract

The risk for suicide in patients with cancer is higher compared to the general population. However, little is known about patients with lung cancer specifically. We therefore implemented a systematic review and random-effects meta-analysis of retrospective cohort studies on suicide in patients with lung cancer. We searched a high number of common databases up to 02/2021. For the systematic review, a total of 23 studies was included. To exclude bias due to patient sample overlap, the meta-analysis was performed on 12 studies. The pooled standardized mortality ratio (SMR) for suicide was 2.95 (95% Confidence Interval (CI) = 2.42–3.60) for patients with lung cancer as compared to the general population. Subgroups with a pronouncedly higher risk for suicide compared to the general population were found for patients living in the USA (SMR = 4.17, 95% CI = 3.88–4.48), with tumors of late stage (SMR = 4.68, 95% CI = 1.28–17.14), and within one year after diagnosis (SMR = 5.00, 95% CI = 4.11–6.08). An increased risk for suicide was found in patients with lung cancer, with subgroups at particular risk. Patients at increased risk should be monitored more closely for suicidality and should receive specialized psycho-oncological and psychiatric care. Further studies should clarify the role of smoking and depressive symptoms on suicidality among lung cancer patients.

Suggested Citation

  • Luisa Hofmann & Michael Heinrich & Hansjörg Baurecht & Berthold Langguth & Peter M. Kreuzer & Helge Knüttel & Michael F. Leitzmann & Corinna Seliger, 2023. "Suicide Mortality Risk among Patients with Lung Cancer—A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 20(5), pages 1-15, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:4146-:d:1080450
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    1. T. D. Stanley, 1998. "New Wine in Old Bottles: A Meta‐Analysis of Ricardian Equivalence," Southern Economic Journal, John Wiley & Sons, vol. 64(3), pages 713-727, January.
    2. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    3. Justin van der Sluis & Mirjam van Praag & Wim Vijverberg, 2005. "Entrepreneurship Selection and Performance: A Meta-Analysis of the Impact of Education in Developing Economies," The World Bank Economic Review, World Bank, vol. 19(2), pages 225-261.
    4. Nicholas G. Zaorsky & Ying Zhang & Leonard Tuanquin & Shirley M. Bluethmann & Henry S. Park & Vernon M. Chinchilli, 2019. "Suicide among cancer patients," Nature Communications, Nature, vol. 10(1), pages 1-7, December.
    5. Tomáš Havránek, 2015. "Measuring Intertemporal Substitution: The Importance Of Method Choices And Selective Reporting," Journal of the European Economic Association, European Economic Association, vol. 13(6), pages 1180-1204, December.
    6. Nolte, Ellen & McKee, Martin, 2011. "Variations in amenable mortality—Trends in 16 high-income nations," Health Policy, Elsevier, vol. 103(1), pages 47-52.
    7. Hui-Chu Lang & Shi-Liang Wu, 2012. "Lifetime costs of the top five cancers in Taiwan," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 13(3), pages 347-353, June.
    8. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    9. Marija Milic & Tatjana Gazibara & Tatjana Pekmezovic & Darija Kisic Tepavcevic & Gorica Maric & Aleksandra Popovic & Jasmina Stevanovic & Karamchand Hukumchand Patil & Hagai Levine, 2020. "Tobacco smoking and health-related quality of life among university students: Mediating effect of depression," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-18, January.
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