IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i5p3918-d1077089.html
   My bibliography  Save this article

Associations of Clusters of Cardiovascular Risk Factors with Insulin Resistance and Β-Cell Functioning in a Working-Age Diabetic-Free Population in Kazakhstan

Author

Listed:
  • Yerbolat Saruarov

    (Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan 161200, Kazakhstan)

  • Gulnaz Nuskabayeva

    (Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan 161200, Kazakhstan)

  • Mehmet Ziya Gencer

    (Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan 161200, Kazakhstan)

  • Karlygash Sadykova

    (Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan 161200, Kazakhstan)

  • Mira Zhunissova

    (Department of Special Clinical Disciplines, Faculty of Medicine, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan 161200, Kazakhstan)

  • Ugilzhan Tatykayeva

    (Department of Human Pathology and Physiology, Faculty of Dentistry, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan 161200, Kazakhstan)

  • Elmira Iskandirova

    (Department of Therapy, Shymkent Medical Institute, Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent 160019, Kazakhstan)

  • Gulmira Sarsenova

    (Department of Therapy, Shymkent Medical Institute, Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent 160019, Kazakhstan)

  • Aigul Durmanova

    (Academic Department of Internal Medicine, University Medical Center, Astana 020000, Kazakhstan)

  • Abduzhappar Gaipov

    (Academic Department of Internal Medicine, University Medical Center, Astana 020000, Kazakhstan
    Department of Medicine, Nazarbayev University School of Medicine, Astana 020000, Kazakhstan)

  • Kuralay Atageldiyeva

    (Academic Department of Internal Medicine, University Medical Center, Astana 020000, Kazakhstan
    Department of Medicine, Nazarbayev University School of Medicine, Astana 020000, Kazakhstan)

  • Antonio Sarría-Santamera

    (Department of Medicine, Nazarbayev University School of Medicine, Astana 020000, Kazakhstan)

Abstract

Cardiovascular risk factors aggregate in determined individuals. Patients with Type 2 diabetes mellitus (T2DM) have higher cardiovascular This study aimed to investigate insulinresistance (IR) and β-cell function using the homeostasis model assessment (HOMA) indexes in a general Kazakh population and determine the effect he effect that cardiovascular factors may have on those indexes. We conducted a cross-sectional study among employees of the Khoja Akhmet Yassawi International Kazakh-Turkish University (Turkistan, Kazakhstan) aged between 27 and 69 years. Sociodemographic variables, anthropometric measurements (body mass, height, waist circumference, hip circumference), and blood pressure were obtained. Fasting blood samples were collected to measure insulin, glucose, total cholesterol (TC), triglycerides (TG), and high- (HDL) andlow-density lipoprotein (LDL) levels. Oral glucose tolerance tests were performed. Hierarchical and K-means cluster analyses were obtained. The final sample was composed of 427 participants. Spearmen correlation analysis showed that cardiovascular parameters were statistically associated with HOMA-β ( p < 0.001) and not with HOMA IR. Participants were aggregated into the three clusters where the cluster with a higher age and cardiovascular risk revealed deficient β-cell functioning, but not IR ( p < 0.000 and p = 0.982). Common and easy to obtain biochemical and anthropometric measurements capturing relevant cardiovascular risk factors have been demonstrated to be associated with significant deficiency in insulin secretion. Although further longitudinal studies of the incidence of T2DM are needed, this study highlights that cardiovascular profiling has a significant role not just for risk stratification of patients for cardiovascular prevention but also for targeted vigilant glucose monitoring.

Suggested Citation

  • Yerbolat Saruarov & Gulnaz Nuskabayeva & Mehmet Ziya Gencer & Karlygash Sadykova & Mira Zhunissova & Ugilzhan Tatykayeva & Elmira Iskandirova & Gulmira Sarsenova & Aigul Durmanova & Abduzhappar Gaipov, 2023. "Associations of Clusters of Cardiovascular Risk Factors with Insulin Resistance and Β-Cell Functioning in a Working-Age Diabetic-Free Population in Kazakhstan," IJERPH, MDPI, vol. 20(5), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:3918-:d:1077089
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/5/3918/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/5/3918/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Antonio Sarría-Santamera & Binur Orazumbekova & Tilektes Maulenkul & Abduzhappar Gaipov & Kuralay Atageldiyeva, 2020. "The Identification of Diabetes Mellitus Subtypes Applying Cluster Analysis Techniques: A Systematic Review," IJERPH, MDPI, vol. 17(24), pages 1-18, December.
    2. Steven E. Kahn & Rebecca L. Hull & Kristina M. Utzschneider, 2006. "Mechanisms linking obesity to insulin resistance and type 2 diabetes," Nature, Nature, vol. 444(7121), pages 840-846, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hidenori Shimizu & Junki Miyamoto & Keiko Hisa & Ryuji Ohue-Kitano & Hiromi Takada & Mayu Yamano & Akari Nishida & Daiki Sasahara & Yuki Masujima & Keita Watanabe & Shota Nishikawa & Sakura Takahashi , 2025. "Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    2. Mingzhu Zhou & Na Zhang & Yu Zhang & Xinyu Yan & Muxia Li & Wen Guo & Xiaohui Guo & Hairong He & Kaiwei Guo & Guansheng Ma, 2021. "Effect of Mobile-Based Lifestyle Intervention on Weight Loss among the Overweight and Obese Elderly Population in China: A Randomized Controlled Trial," IJERPH, MDPI, vol. 18(16), pages 1-13, August.
    3. Wiki, Jesse & Kingham, Simon & Campbell, Malcolm, 2021. "A geospatial analysis of Type 2 Diabetes Mellitus and the food environment in urban New Zealand," Social Science & Medicine, Elsevier, vol. 288(C).
    4. Xin Guo & Li Shen & Jing Dou & Yaogai Lv & Anning Zhang & Fanchao Shi & Zhiqiang Xue & Yaqin Yu & Lina Jin & Yan Yao, 2017. "Associations of Fasting Blood Glucose with Influencing Factors in Northeast China: A Quantile Regression Analysis," IJERPH, MDPI, vol. 14(11), pages 1-11, November.
    5. Xuanming Guo & Pallavi Asthana & Lixiang Zhai & Ka Wing Cheng & Susma Gurung & Jiangang Huang & Jiayan Wu & Yijing Zhang & Arun Kumar Mahato & Mart Saarma & Mart Ustav & Hiu Yee Kwan & Aiping Lyu & Ku, 2024. "Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Aguilar, Arturo & Gutierrez, Emilio & Seira, Enrique, 2021. "The effectiveness of sin food taxes: Evidence from Mexico," Journal of Health Economics, Elsevier, vol. 77(C).
    7. Dezhong Chen & Ziyun Liang & Huimin Sun & Ciyong Lu & Weiqing Chen & Harry H. X. Wang & Vivian Yawei Guo, 2021. "Association between Hypertriglyceridemic-Waist Phenotype and Risk of Type 2 Diabetes Mellitus in Middle-Aged and Older Chinese Population: A Longitudinal Cohort Study," IJERPH, MDPI, vol. 18(18), pages 1-9, September.
    8. Tashi Dendup & Xiaoqi Feng & Stephanie Clingan & Thomas Astell-Burt, 2018. "Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review," IJERPH, MDPI, vol. 15(1), pages 1-25, January.
    9. Antonio Bernabe-Ortiz & Diego B. Borjas-Cavero & Jimmy D. Páucar-Alfaro & Rodrigo M. Carrillo-Larco, 2022. "Multimorbidity Patterns among People with Type 2 Diabetes Mellitus: Findings from Lima, Peru," IJERPH, MDPI, vol. 19(15), pages 1-11, July.
    10. Benedetta Pongiglione & George B Ploubidis & Jennifer B Dowd, 2022. "Older Adults in the United States Have Worse Cardiometabolic Health Compared to England," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 77(Supplemen), pages 167-176.
    11. Rafael Molina-Luque & Aina M Yañez & Miquel Bennasar-Veny & Manuel Romero-Saldaña & Guillermo Molina-Recio & Ángel-Arturo López-González, 2020. "A Comparison of Equation Córdoba for Estimation of Body Fat (ECORE-BF) with Other Prediction Equations," IJERPH, MDPI, vol. 17(21), pages 1-11, October.
    12. Margherita d’Errico & Milena Pavlova & Federico Spandonaro, 2022. "The economic burden of obesity in Italy: a cost-of-illness study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 23(2), pages 177-192, March.
    13. Ravinder Naik Dharavath & Vibhu Kumar & Vibhu Kumar, 2017. "Zymosan A, an Old Tool in Experimental Pharmacology with Newer Applications," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 4(3), pages 58-61, October.
    14. Kameel Mungrue, 2017. "The Dawn (Diabetes: Attitudes, Wishes and Needs) of Type 2 Diabetes Mellitus in Trinidad, A Small Middle Income Developing Country," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 2(2), pages 1-7, May.
    15. Sofia I Iqbal Kring & John Barefoot & Beverly H Brummett & Stephen H Boyle & Ilene C Siegler & Søren Toubro & Torben Hansen & Arne Astrup & Oluf Pedersen & Redford B Williams & Thorkild I A Sørensen, 2011. "Associations between APOE Variants and Metabolic Traits and the Impact of Psychological Stress," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-5, January.
    16. Artak Labadzhyan & Jinrui Cui & Miklós Péterfy & Xiuqing Guo & Yii-Der I Chen & Willa A Hsueh & Jerome I Rotter & Mark O Goodarzi, 2016. "Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-11, November.
    17. Khurshid Ahmad Khan & Muhammad Shahzad Saleem & Kinza Khan & Najam-un-Nasir & Zohaib A. Khan, 2014. "Vitamin D Deficiency and Type 2 Diabetes Mellitus," International Journal of Sciences, Office ijSciences, vol. 3(04), pages 70-74, April.
    18. Maja Rubinowicz-Zasada & Ewa Kucio & Anna Polak & Petr Stastny & Krzysztof Wierzbicki & Piotr Król & Cezary Kucio, 2021. "The Combined Effect of Neuromuscular Electrical Stimulation and Insulin Therapy on Glycated Hemoglobin Concentrations, Lipid Profiles and Hemodynamic Parameters in Patients with Type-2-Diabetes and He," IJERPH, MDPI, vol. 18(7), pages 1-13, March.
    19. Mengling Tang & Kun Chen & Fangxing Yang & Weiping Liu, 2014. "Exposure to Organochlorine Pollutants and Type 2 Diabetes: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.
    20. Nicolas Todd & Mikko Myrskylä, 2022. "Projection of US adult obesity trends based on individual BMI trajectories," MPIDR Working Papers WP-2022-034, Max Planck Institute for Demographic Research, Rostock, Germany.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:3918-:d:1077089. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.