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Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study

Author

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  • Marisa Baré

    (Institutional Committee for the Improvement of Clinical Practice Adequacy, Clinical Epidemiology and Cancer Screening Department, CRiSP Research Group, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
    Research Network on Health Services in Chronic Patients (REDISSEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), ISCIII, 28029 Madrid, Spain)

  • Marina Lleal

    (Institutional Committee for the Improvement of Clinical Practice Adequacy, Clinical Epidemiology and Cancer Screening Department, CRiSP Research Group, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
    Department of Paediatrics, Obstetrics and Gynaecology, Preventive Medicine and Public Health, Autonomous University of Barcelona, Bellaterra, 08193 Barcelona, Spain)

  • Daniel Sevilla-Sánchez

    (Pharmacy Department, Parc Sanitari Pere Virgili, 08023 Barcelona, Spain)

  • Sara Ortonobes

    (Pharmacy Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Universitat Autònoma de Barcelona, 08208 Sabadell, Spain)

  • Susana Herranz

    (Research Network on Health Services in Chronic Patients (REDISSEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Acute Care Geriatric Unit, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Universitat Autònoma de Barcelona, 08208 Sabadell, Spain)

  • Olivia Ferrandez

    (Pharmacy Department, Consorci Parc de Salut MAR, 08003 Barcelona, Spain)

  • Celia Corral-Vázquez

    (Research Network on Health Services in Chronic Patients (REDISSEC), Instituto de Salud Carlos III, 28029 Madrid, Spain)

  • Núria Molist

    (Geriatrics Department-C3RG Research Ggoup, Consorci Hospitalari de Vic, 08500 Vic, Spain)

  • Gloria Julia Nazco

    (Pharmacy Department, Hospital Universitario de Canarias, 38320 La Laguna, Spain)

  • Candelaria Martín-González

    (Internal Medicine Department, Hospital Universitario de Canarias, 38320 La Laguna, Spain)

  • Miguel Ángel Márquez

    (Geriatrics Department, Consorci Parc de Salut MAR, 08003 Barcelona, Spain)

  • on behalf of the MoPIM Study Group

    (Membership of the Group Name is provided in the Acknowledgments.)

Abstract

There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (≥65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% ≥85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode.

Suggested Citation

  • Marisa Baré & Marina Lleal & Daniel Sevilla-Sánchez & Sara Ortonobes & Susana Herranz & Olivia Ferrandez & Celia Corral-Vázquez & Núria Molist & Gloria Julia Nazco & Candelaria Martín-González & Migue, 2023. "Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study," IJERPH, MDPI, vol. 20(4), pages 1-15, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3639-:d:1072809
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    References listed on IDEAS

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    1. Karolina Agur & Gary McLean & Kate Hunt & Bruce Guthrie & Stewart W. Mercer, 2016. "How Does Sex Influence Multimorbidity? Secondary Analysis of a Large Nationally Representative Dataset," IJERPH, MDPI, vol. 13(4), pages 1-12, March.
    2. David Westergaard & Pope Moseley & Freja Karuna Hemmingsen Sørup & Pierre Baldi & Søren Brunak, 2019. "Population-wide analysis of differences in disease progression patterns in men and women," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    3. Lorraine Greaves & Stacey A. Ritz, 2022. "Sex, Gender and Health: Mapping the Landscape of Research and Policy," IJERPH, MDPI, vol. 19(5), pages 1-13, February.
    4. Gabriele Bolte & Katharina Jacke & Katrin Groth & Ute Kraus & Lisa Dandolo & Lotta Fiedel & Malgorzata Debiak & Marike Kolossa-Gehring & Alexandra Schneider & Kerstin Palm, 2021. "Integrating Sex/Gender into Environmental Health Research: Development of a Conceptual Framework," IJERPH, MDPI, vol. 18(22), pages 1-18, November.
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