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Population-wide analysis of differences in disease progression patterns in men and women

Author

Listed:
  • David Westergaard

    (University of Copenhagen)

  • Pope Moseley

    (University of Copenhagen)

  • Freja Karuna Hemmingsen Sørup

    (University of Copenhagen
    Roskilde University Hospital)

  • Pierre Baldi

    (University of California)

  • Søren Brunak

    (University of Copenhagen)

Abstract

Sex-stratified medicine is a fundamentally important, yet understudied, facet of modern medical care. A data-driven model for how to systematically analyze population-wide, longitudinal differences in hospital admissions between men and women is needed. Here, we demonstrate a systematic analysis of all diseases and disease co-occurrences in the complete Danish population using the ICD-10 and Global Burden of Disease terminologies. Incidence rates of single diagnoses are different for men and women in most cases. The age at first diagnosis is typically lower for men, compared to women. Men and women share many disease co-occurrences. However, many sex-associated incongruities not linked directly to anatomical or genomic differences are also found. Analysis of multi-step trajectories uncover differences in longitudinal patterns, for example concerning injuries and substance abuse, cancer, and osteoporosis. The results point towards the need for an increased focus on sex-stratified medicine to elucidate the origins of the socio-economic and ethological differences.

Suggested Citation

  • David Westergaard & Pope Moseley & Freja Karuna Hemmingsen Sørup & Pierre Baldi & Søren Brunak, 2019. "Population-wide analysis of differences in disease progression patterns in men and women," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08475-9
    DOI: 10.1038/s41467-019-08475-9
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    Cited by:

    1. David Westergaard & Frederik Hytting Jørgensen & Jens Waaben & Alexander Wolfgang Jung & Mette Lademann & Thomas Folkmann Hansen & Jolien Cremers & Sisse Rye Ostrowski & Ole Birger Vesterager Pedersen, 2024. "Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Marisa Baré & Marina Lleal & Daniel Sevilla-Sánchez & Sara Ortonobes & Susana Herranz & Olivia Ferrandez & Celia Corral-Vázquez & Núria Molist & Gloria Julia Nazco & Candelaria Martín-González & Migue, 2023. "Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study," IJERPH, MDPI, vol. 20(4), pages 1-15, February.
    3. Rebecca K. Rechlin & Tallinn F. L. Splinter & Travis E. Hodges & Arianne Y. Albert & Liisa A. M. Galea, 2022. "An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Andreas Höhn & Anna Oksuzyan & Rune Lindahl-Jacobsen & Kaare Christensen & Rosie Seaman, 2021. "Gender differences in time to first hospital admission at age 60 in Denmark, 1995–2014," European Journal of Ageing, Springer, vol. 18(4), pages 443-451, December.

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