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A Meta-Analysis of the Influence on Inflammatory Factors in Type 2 Diabetes among Middle-Aged and Elderly Patients by Various Exercise Modalities

Author

Listed:
  • Weijun Yang

    (Sports Coaching College, Beijing Sport University, Beijing 100084, China
    These authors contributed equally to this work.)

  • Haotian Jiao

    (Sports Coaching College, Beijing Sport University, Beijing 100084, China
    School of Education, Beijing Sport University, Beijing 100084, China
    These authors contributed equally to this work.)

  • Yizhang Xue

    (Sports Coaching College, Beijing Sport University, Beijing 100084, China)

  • Lishuo Wang

    (School of Management Engineering and E-Commerce, Zhejiang Gongshang University, Hangzhou 310018, China)

  • Ye Zhang

    (Sports Coaching College, Beijing Sport University, Beijing 100084, China)

  • Boqian Wang

    (Tourism Management, Beijing Sport University, Beijing 100084, China)

  • Ziyi Teng

    (School of Sport Science, Beijing Sport University, Beijing 100084, China)

  • Junyan Li

    (School of Sport Science, Beijing Sport University, Beijing 100084, China)

  • Haotian Zhao

    (Department of Physical Education, Jiangnan University, Wuxi 214122, China)

  • Chang Liu

    (School of Sport Science, Beijing Sport University, Beijing 100084, China)

Abstract

The purpose of this study was to investigate the effects of various exercise modalities on inflammatory factors in middle-aged and elderly patients with type 2 diabetes (MEPT2D), as lifestyle changes, such as physical activity and dietary modifications, are considered important in the prevention of type 2 diabetes. For the study methodology, Pubmed, CNKI, EBSCO, Wanfang Data, and Web of Science were selected for the search. The methodological quality of the included studies was assessed by the Cochrane Risk of Bias (ROB) tool, and statistically analyzed using the RevMan 5.4.1 analysis software, which included 18 investigations involving 853 study subjects. Meta-analysis findings indicated that aerobic training (AT), resistance training (RT), combined training (CT), and high-intensity interval training (HIIT) showed significant reductions in CRP, TNF-α, IL-6, and IL-10 levels in MEPT2D. Among them, HIIT was superior to other training modalities in reducing TNF-α levels, while CT was superior to AT, RT, and HIIT in decreasing IL-6, IL-10, and CRP in MEPT2D. Meanwhile, RT had limited effects in reducing CRP and TNF-α levels in MEPT2D. However, HIIT had no significant effect on IL-6 and IL-10 in MEPT2D. In conclusion, long-term regular AT, RT, CT, and HIIT all contributed to the reduction of inflammatory status (CRP, TNF-α, IL-6, and IL-10) in MEPT2D, while CT (for CRP, IL-6, and IL-10) and HIIT (for TNF-α) represent the best approaches to counteract the inflammatory response in MEPT2D.

Suggested Citation

  • Weijun Yang & Haotian Jiao & Yizhang Xue & Lishuo Wang & Ye Zhang & Boqian Wang & Ziyi Teng & Junyan Li & Haotian Zhao & Chang Liu, 2023. "A Meta-Analysis of the Influence on Inflammatory Factors in Type 2 Diabetes among Middle-Aged and Elderly Patients by Various Exercise Modalities," IJERPH, MDPI, vol. 20(3), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:3:p:1783-:d:1040146
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    References listed on IDEAS

    as
    1. Gabriela de Oliveira Teles & Carini Silva da Silva & Vinicius Ramos Rezende & Ana Cristina Silva Rebelo, 2022. "Acute Effects of High-Intensity Interval Training on Diabetes Mellitus: A Systematic Review," IJERPH, MDPI, vol. 19(12), pages 1-14, June.
    2. José Manuel Leiva-Valderrama & Adrián Montes-de-Oca-Garcia & Edgardo Opazo-Diaz & Jesus G. Ponce-Gonzalez & Guadalupe Molina-Torres & Daniel Velázquez-Díaz & Alejandro Galán-Mercant, 2021. "Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review," IJERPH, MDPI, vol. 18(23), pages 1-19, November.
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