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Prevention of Type 1 Diabetes in Children: A Worthy Challenge?

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  • Diletta Maria Francesca Ingrosso

    (Department of Pediatrics, University of Chieti, Via dei Vestini, 66100 Chieti, Italy)

  • Maria Teresa Quarta

    (Department of Pediatrics, University of Chieti, Via dei Vestini, 66100 Chieti, Italy)

  • Alessia Quarta

    (Department of Pediatrics, University of Chieti, Via dei Vestini, 66100 Chieti, Italy)

  • Francesco Chiarelli

    (Department of Pediatrics, University of Chieti, Via dei Vestini, 66100 Chieti, Italy)

Abstract

Nowadays, the development of new immuno-therapeutic drugs has made it possible to alter the course of many autoimmune diseases. Type 1 diabetes is a chronic disease with a progressive dependence on exogenous insulin administration. The ability to intercept individuals at high risk of developing type 1 diabetes is the first step toward the development of therapies that can delay the process of β-cell destruction, thus permitting a better glycemic control and reducing the incidence of ketoacidosis. The knowledge of the main pathogenetic mechanisms underlying the three stages of the disease may be helpful to identify the best immune therapeutic approach. In this review, we aim to give an overview of the most important clinical trials conducted during the primary, secondary and tertiary phases of prevention.

Suggested Citation

  • Diletta Maria Francesca Ingrosso & Maria Teresa Quarta & Alessia Quarta & Francesco Chiarelli, 2023. "Prevention of Type 1 Diabetes in Children: A Worthy Challenge?," IJERPH, MDPI, vol. 20(11), pages 1-15, May.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:11:p:5962-:d:1156640
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    References listed on IDEAS

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    2. Tommi Vatanen & Eric A. Franzosa & Randall Schwager & Surya Tripathi & Timothy D. Arthur & Kendra Vehik & Åke Lernmark & William A. Hagopian & Marian J. Rewers & Jin-Xiong She & Jorma Toppari & Anette, 2018. "The human gut microbiome in early-onset type 1 diabetes from the TEDDY study," Nature, Nature, vol. 562(7728), pages 589-594, October.
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