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Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions

Author

Listed:
  • Che-Yu Kuo

    (Division of Occupational Medicine, Department of Emergency, Taichung Veterans General Hospital, Taichung 40705, Taiwan)

  • Cheng-Fu Lin

    (Division of Occupational Medicine, Department of Emergency, Taichung Veterans General Hospital, Taichung 40705, Taiwan
    Center for Geriatrics & Gerontology, Taichung Veterans General Hospital, Taichung 40705, Taiwan)

  • Shih-Yu Chung

    (Division of Family Medicine, Department of Internal Medicine, Taichung Veterans General Hospital Puli Branch, Nantou 54552, Taiwan)

  • Yu-Li Lin

    (Division of Occupational Medicine, Department of Emergency, Taichung Veterans General Hospital, Taichung 40705, Taiwan
    School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan)

  • Wei-Min Chu

    (Division of Occupational Medicine, Department of Emergency, Taichung Veterans General Hospital, Taichung 40705, Taiwan
    School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Family Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan)

  • Chun-Chieh Chen

    (School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

  • Yu-Tse Tsan

    (Division of Occupational Medicine, Department of Emergency, Taichung Veterans General Hospital, Taichung 40705, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan)

Abstract

Nickel is a heavy metal used in many industries. Nickel exposure can induce respiratory diseases and allergic reactions, and increase cancer risk. This study evaluated the introduction of a grinding and polishing system to prevent injuries from nickel toxicity in workers. We performed a controlled, interventional, before-and-after study from January 2018 to December 2019 at a faucet component industrial manufacturing site. Results from workplace environmental monitoring, questionnaire responses, and biomonitoring were collected before and after the intervention. Thirty-seven workers (100% men) aged 25.0 (interquartile range (IQR): 22.0–33.5) years were categorized into two groups, those with and without nickel exposure. In the exposed group, the median exposure time was 18.0 months (IQR 14.0–20.0 months). Urinary nickel concentration was lower in the exposed group than in the non-exposed group (13.8 (IQR 1.7–20.7); 23.1 (IQR 11.3–32.8) μg/g creatinine, respectively; p = 0.047). The median urinary nickel concentration was lower in the second year than in the first year (17.4 (IQR 2.2–27.4), 7.7 (IQR 4.3–18.5) μg/g creatinine, respectively; p = 0.022). Significant reductions in urinary nickel concentration were observed following the intervention and educational program. Thus, biomonitoring of urinary nickel concentration can successfully reflect the effectiveness of interventions and their relationship to nickel exposure.

Suggested Citation

  • Che-Yu Kuo & Cheng-Fu Lin & Shih-Yu Chung & Yu-Li Lin & Wei-Min Chu & Chun-Chieh Chen & Yu-Tse Tsan, 2022. "Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions," IJERPH, MDPI, vol. 19(8), pages 1-10, April.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:8:p:4887-:d:795865
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    References listed on IDEAS

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    1. Giuseppe Genchi & Alessia Carocci & Graziantonio Lauria & Maria Stefania Sinicropi & Alessia Catalano, 2020. "Nickel: Human Health and Environmental Toxicology," IJERPH, MDPI, vol. 17(3), pages 1-21, January.
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