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Conjunctional Relationship between Serum Uric Acid and Serum Nickel with Non-Alcoholic Fatty Liver Disease in Men: A Cross-Sectional Study

Author

Listed:
  • Chili Liu

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

  • Wannian Liu

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

  • Guofu Zhang

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

  • Yongbin Wang

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

  • Jing Jiang

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

  • Zhongzhi Yang

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

  • Weidong Wu

    (School of Public Health, Xinxiang Medical University, Xinxiang 453003, China)

Abstract

Serum uric acid (SUA) and heavy metals are closely related to non-alcoholic fatty liver disease (NAFLD). Yet, the conjunctional relationship between SUA and serum nickel (Ni) concentrations with the risk of NAFLD in men has not yet been investigated. Therefore, we designed this cross-sectional study to investigate the association of SUA or serum Ni with NAFLD in men. The cross-sectional study was based on data obtained from a prospective cohort study of common chronic non-communicable diseases in Central China, conducted in Xinxiang city, Central China’s Henan Province, between April and June 2017. A total of 1709 male participants completed the physical examination. B-ultrasound was used to examine the liver and to diagnose NAFLD. Binary logistic regression models and restricted cubic splines were performed to estimate the association of the SUA and serum Ni with NAFLD. The prevalence of NAFLD among 1709 male participants was 46.6%. After adjusting for potential confounders, with the highest quartile compared to those with the lowest quartile, SUA (OR = 1.579, 95% CI: 1.140–2.189) and serum Ni (OR = 1.896, 95% CI: 1.372–2.625) were associated with NAFLD, respectively. At the same time, the associations for the second and third SUA quartiles were null. Restricted cubic splines showed a positive linear relationship between serum Ni (ln-transformed) and NAFLD risk. Intriguingly, high SUA and high Ni (OR = 2.370, 95% CI: 1.577–3.597) increased the risk of NAFLD, compared with those with low SUA and low Ni. Our findings demonstrate a positive linear trend between serum Ni concentrations and NAFLD risk. Men with elevated serum Ni had a higher risk of developing NAFLD when compared to those with high SUA. Furthermore, the conjunctional relationship of SUA and serum Ni with NAFLD risk was observed in men.

Suggested Citation

  • Chili Liu & Wannian Liu & Guofu Zhang & Yongbin Wang & Jing Jiang & Zhongzhi Yang & Weidong Wu, 2022. "Conjunctional Relationship between Serum Uric Acid and Serum Nickel with Non-Alcoholic Fatty Liver Disease in Men: A Cross-Sectional Study," IJERPH, MDPI, vol. 19(11), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6424-:d:823766
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    References listed on IDEAS

    as
    1. Giuseppe Genchi & Alessia Carocci & Graziantonio Lauria & Maria Stefania Sinicropi & Alessia Catalano, 2020. "Nickel: Human Health and Environmental Toxicology," IJERPH, MDPI, vol. 17(3), pages 1-21, January.
    2. Sandra Cortés & Liliana Zúñiga-Venegas & Floria Pancetti & Alejandra Covarrubias & Muriel Ramírez-Santana & Héctor Adaros & Luis Muñoz, 2021. "A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile," IJERPH, MDPI, vol. 18(4), pages 1-11, February.
    3. Hongbin Li & Meihao Guo & Zhen An & Jun Meng & Jing Jiang & Jie Song & Weidong Wu, 2020. "Prevalence and Risk Factors of Metabolic Associated Fatty Liver Disease in Xinxiang, China," IJERPH, MDPI, vol. 17(6), pages 1-13, March.
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