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Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis

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  • Lysleine Alves Deus

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Hugo de Luca Corrêa

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Rodrigo Vanerson Passos Neves

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Andrea Lucena Reis

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Fernando Sousa Honorato

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Victor Lopes Silva

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Michel Kendy Souza

    (Department of Nephrology, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Thaís Branquinho de Araújo

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Lucas Santos de Gusmão Alves

    (Graduate Program in Medicine, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Caio Victor Sousa

    (Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA)

  • Thaís Lucena Reis

    (Medical Graduate Program, University of Brasília, Brasília 70910-900, Brazil)

  • Lucas Soares de Aguiar

    (Medical Graduate Program, University of Brasília, Brasília 70910-900, Brazil)

  • Herbert Gustavo Simões

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Jonato Prestes

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Gislane Ferreira Melo

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

  • Thiago Santos Rosa

    (Graduate Program in Physical Education, Catholic University of Brasília, Brasília 71966-700, Brazil)

Abstract

Background: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. Methods: Two randomized groups of hemodialysis patients: control (CTL, n = 76/F36; 66.33 ± 3.88 years) and RT ( n = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes—SF36), and Beck Depression Inventory was applied. Results: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; p = 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; p = 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT,680.8 ± 225.2 vs. CTL,589.5 ± 195.9; p = 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; p = 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; p = 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; p = 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; p = 0.001). Quality of life and mental health increased ( p = 0.001) for RT, but did not change for CTL ( p = 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip ( p = 0.001). Conclusions: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients.

Suggested Citation

  • Lysleine Alves Deus & Hugo de Luca Corrêa & Rodrigo Vanerson Passos Neves & Andrea Lucena Reis & Fernando Sousa Honorato & Victor Lopes Silva & Michel Kendy Souza & Thaís Branquinho de Araújo & Lucas , 2021. "Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axi," IJERPH, MDPI, vol. 18(21), pages 1-13, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11299-:d:666270
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    References listed on IDEAS

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    1. Adam Dinoff & Nathan Herrmann & Walter Swardfager & Celina S Liu & Chelsea Sherman & Sarah Chan & Krista L Lanctôt, 2016. "The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-21, September.
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