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Inactivation of Spores and Vegetative Forms of Clostridioides difficile by Chemical Biocides: Mechanisms of Biocidal Activity, Methods of Evaluation, and Environmental Aspects

Author

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  • Weronika Augustyn

    (MEXEO-Wiesław Hreczuch, Energetyków 9, 47-225 Kędzierzyn-Koźle, Poland
    Environmental Biotechnology Department, Silesian University of Technology, Faculty of Power and Environmental Engineering, 44-100 Gliwice, Poland)

  • Arkadiusz Chruściel

    (MEXEO-Wiesław Hreczuch, Energetyków 9, 47-225 Kędzierzyn-Koźle, Poland)

  • Wiesław Hreczuch

    (MEXEO-Wiesław Hreczuch, Energetyków 9, 47-225 Kędzierzyn-Koźle, Poland)

  • Joanna Kalka

    (Environmental Biotechnology Department, Silesian University of Technology, Faculty of Power and Environmental Engineering, 44-100 Gliwice, Poland)

  • Patryk Tarka

    (Department of Social Medicine and Public Health, Medical University of Warsaw, 02-007 Warszawa, Poland)

  • Wojciech Kierat

    (Department of Digital Systems, Silesian University of Technology, 44-100 Gliwice, Poland)

Abstract

Clostridioides difficile infections (CDIs) are the most common cause of acquired diseases in hospitalized patients. Effective surface disinfection, focused on the inactivation of the spores of this pathogen, is a decisive factor in reducing the number of nosocomial cases of CDI infections. An efficient disinfection procedure is the result of both the properties of the biocidal agent used and the technology of its implementation as well as a reliable, experimental methodology for assessing the activity of the biocidal active substance based on laboratory models that adequately represent real clinical conditions. This study reviews the state of knowledge regarding the properties and biochemical basis of the action mechanisms of sporicidal substances, with emphasis on chlorine dioxide (ClO 2 ). Among the analyzed biocides, in addition to ClO 2 , active chlorine, hydrogen peroxide, peracetic acid, and glutaraldehyde were characterized. Due to the relatively high sporicidal effectiveness and effective control of bacterial biofilm, as well as safety in a health and environmental context, the use of ClO 2 is an attractive alternative in the control of nosocomial infections of CD etiology. In terms of the methods of assessing the biocidal effectiveness, suspension and carrier standards are discussed.

Suggested Citation

  • Weronika Augustyn & Arkadiusz Chruściel & Wiesław Hreczuch & Joanna Kalka & Patryk Tarka & Wojciech Kierat, 2022. "Inactivation of Spores and Vegetative Forms of Clostridioides difficile by Chemical Biocides: Mechanisms of Biocidal Activity, Methods of Evaluation, and Environmental Aspects," IJERPH, MDPI, vol. 19(2), pages 1-17, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:750-:d:721567
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    References listed on IDEAS

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    1. Wojciech Kierat & Weronika Augustyn & Piotr Koper & Miroslawa Pawlyta & Arkadiusz Chrusciel & Bernard Wyrwol, 2020. "The Use of UVC Irradiation to Sterilize Filtering Facepiece Masks Limiting Airborne Cross-Infection," IJERPH, MDPI, vol. 17(20), pages 1-14, October.
    2. Kate E. Jones & Nikkita G. Patel & Marc A. Levy & Adam Storeygard & Deborah Balk & John L. Gittleman & Peter Daszak, 2008. "Global trends in emerging infectious diseases," Nature, Nature, vol. 451(7181), pages 990-993, February.
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