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Commentary: Zebrafish as a Model for Osteoporosis—An Approach to Accelerating Progress in Drug and Exercise-Based Treatment

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  • Natnaiel M. Dubale

    (Department of Biology, Trent University, Peterborough, ON K9L 0G2, Canada)

  • Carolyn M. Kapron

    (Department of Biology, Trent University, Peterborough, ON K9L 0G2, Canada)

  • Sarah L. West

    (Department of Biology, Trent University, Peterborough, ON K9L 0G2, Canada
    Department of Kinesiology, Trent University, Peterborough, ON K9L 0G2, Canada
    Trent/Fleming School of Nursing, Trent University, Peterborough, ON K9L 0G2, Canada)

Abstract

Osteoporosis (OP) is a degenerative disease characterized by reduced bone strength and increased fracture risk. As the global population continues to age, the prevalence and economic burden of osteoporosis can be expected to rise substantially, but there remain various gaps in the field of OP care. For instance, there is a lack of anti-fracture drugs with proven long-term efficacy. Likewise, though exercise remains widely recommended in OP prevention and management, data regarding the safety and efficacy for patients after vertebral fracture remain limited. This lack of evidence may be due to the cost and inherent difficulties associated with exercise-based OP research. Thus, the current research landscape highlights the need for novel research strategies that accelerate OP drug discovery and allow for the low-cost study of exercise interventions. Here, we outline an example of one strategy, the use of zebrafish, which has emerged as a potential model for the discovery of anti-osteoporosis therapeutics and study of exercise interventions. The strengths, limitations, and potential applications of zebrafish in OP research will be outlined.

Suggested Citation

  • Natnaiel M. Dubale & Carolyn M. Kapron & Sarah L. West, 2022. "Commentary: Zebrafish as a Model for Osteoporosis—An Approach to Accelerating Progress in Drug and Exercise-Based Treatment," IJERPH, MDPI, vol. 19(23), pages 1-7, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15866-:d:987197
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    References listed on IDEAS

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    1. Kerstin Howe & Matthew D. Clark & Carlos F. Torroja & James Torrance & Camille Berthelot & Matthieu Muffato & John E. Collins & Sean Humphray & Karen McLaren & Lucy Matthews & Stuart McLaren & Ian Sea, 2013. "The zebrafish reference genome sequence and its relationship to the human genome," Nature, Nature, vol. 496(7446), pages 498-503, April.
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