IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i23p15859-d987139.html
   My bibliography  Save this article

Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise

Author

Listed:
  • Mikołaj Maga

    (Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland
    Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland)

  • Martyna Schönborn

    (Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland
    Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland)

  • Agnieszka Wachsmann-Maga

    (Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland
    Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland)

  • Agnieszka Śliwka

    (Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland)

  • Jakub Krężel

    (Clinical Department of Angiology, University Hospital in Krakow, 30-688 Krakow, Poland)

  • Aleksandra Włodarczyk

    (Department of Angiology, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland)

  • Marta Olszewska

    (Department of Pediatrics, Institute of Pediatrics, Faculty of Medicine, Jagiellonian University Medical College, 30-663 Krakow, Poland)

  • Roman Nowobilski

    (Department of Rehabilitation in Internal Diseases, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland)

Abstract

Blood-flow-restricted exercise (BFRE) has been gaining constantly increasing interest in rehabilitation, but its influence on endothelial functions has not been well studied yet. Our aim is to examine the influence of low-resistance BFRE on endothelial functions and angiogenesis. This prospective cross-over study involved 35 young healthy adults. They conducted a 21-min low-resistant exercise with blood flow restricted by pressure cuffs placed on arms and tights. They also did the same training but without blood flow restriction. Endothelial parameters and angiogenesis biomarkers were evaluated before and up to 20 min after exercise. Both types of exercise increased Flow-Mediated Dilatation (FMD) but elevation after BFRE was more significant compared to the controls. The stiffness index decreased only after BFRE, while the reflection index decreased significantly after both types of exercise but was higher after BFRE. Platelet endothelial cell adhesion molecule (PECAM-1) and vascular endothelial growth factor receptor 2 (VEGFR-2) concentrations were increased by both exercise types but elevations were higher after BFRE compared to the controls. Only BFRE elevated the mean serum CD34 protein concentration. Based on these results, we can assume that low-resistance BFR exercise stimulates angiogenesis and improves endothelial functions more significantly compared to the same training performed without blood flow restriction.

Suggested Citation

  • Mikołaj Maga & Martyna Schönborn & Agnieszka Wachsmann-Maga & Agnieszka Śliwka & Jakub Krężel & Aleksandra Włodarczyk & Marta Olszewska & Roman Nowobilski, 2022. "Stimulation of the Vascular Endothelium and Angiogenesis by Blood-Flow-Restricted Exercise," IJERPH, MDPI, vol. 19(23), pages 1-10, November.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15859-:d:987139
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/23/15859/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/23/15859/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Tianqi Zhang & Guixian Tian & Xing Wang, 2022. "Effects of Low-Load Blood Flow Restriction Training on Hemodynamic Responses and Vascular Function in Older Adults: A Meta-Analysis," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    2. Lee J. Winchester & Morgan T. Blake & Abby R. Fleming & Elroy J. Aguiar & Michael V. Fedewa & Michael R. Esco & Ryan L. Earley, 2022. "Hemodynamic Responses to Resistance Exercise with Blood Flow Restriction Using a Practical Method Versus a Traditional Cuff-Inflation System," IJERPH, MDPI, vol. 19(18), pages 1-13, September.
    3. Fabiano Aparecido Pinheiro & Flávio Oliveira Pires & Bent R. Rønnestad & Felipe Hardt & Miguel Soares Conceição & Manoel E. Lixandrão & Ricardo Berton & Valmor Tricoli, 2022. "The Effect of Low-intensity Aerobic Training Combined with Blood Flow Restriction on Maximal Strength, Muscle Mass, and Cycling Performance in a Cyclist with Knee Displacement," IJERPH, MDPI, vol. 19(5), pages 1-7, March.
    4. Monika Starzak & Agata Stanek & Grzegorz K. Jakubiak & Armand Cholewka & Grzegorz Cieślar, 2022. "Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?," IJERPH, MDPI, vol. 19(16), pages 1-14, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shufan Li & Peng Wang & Xin Xin & Xiaojing Zhou & Jing Wang & Jinlei Zhao & Xing Wang, 2023. "The Effect of Low Intensity Resistance Training with Blood Flow Restriction on Fall Resistance in Middle-Aged and Older Adults: A Meta-Analysis," IJERPH, MDPI, vol. 20(6), pages 1-15, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yuting Zhang & Yingcai Xie & Lingling Huang & Yan Zhang & Xilin Li & Qiyu Fang & Qun Wang, 2022. "Association of Sleep Duration and Self-Reported Insomnia Symptoms with Metabolic Syndrome Components among Middle-Aged and Older Adults," IJERPH, MDPI, vol. 19(18), pages 1-11, September.
    2. Bjoern Hornikel & Keith S. Saffold & Michael R. Esco & Jacob A. Mota & Michael V. Fedewa & Stefanie A. Wind & Tiffany L. Adams & Lee J. Winchester, 2023. "Acute Responses to High-Intensity Back Squats with Bilateral Blood Flow Restriction," IJERPH, MDPI, vol. 20(4), pages 1-15, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15859-:d:987139. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.