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Psychotic Disorders in the Course of SARS-CoV-2 Infection or Uncomplicated Amantadine Treatment?—Case Report

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  • Dominika Tatar

    (Clinical Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland)

  • Krzysztof Świerzy

    (Clinical Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland)

  • Michał Błachut

    (Clinical Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland)

  • Karina Badura Brzoza

    (Clinical Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland)

Abstract

The mental health impact of SARS-CoV-2 infection is currently the subject of intense research. Mental disorders in the course of coronavirus infection are non-specific. They most often have a sudden onset and short-term course and resolve spontaneously or after the administration of low doses of antipsychotic drugs. At the same time, attempts have been made to develop recommendations for COVID-19 therapy. Single reports suggest the effectiveness of amantadine in the treatment. The mechanism of action of the drug in this case is not known; it is expected that amantadine, by reducing the expression of the cathepsin L gene, may interfere with SARS-CoV-2 replication. In addition, this drug stimulates dopaminergic transmission, which may result in numerous side effects, often of a neuropsychological nature, the most common of which are visual hallucinations. Therefore, it is extremely difficult to unequivocally diagnose the cause of mental disorders among patients with SARS-CoV-2 infection who took amatatide for off-label treatment. A clear assessment of whether the psychological symptoms in this group of patients are the primary or secondary clinical manifestation of the infection or a complication of amantadine treatment is difficult. In this context, we attempted to describe a case of a patient with psychotic symptoms who was confirmed with SARS-CoV-2 infection and treated with amantadine.

Suggested Citation

  • Dominika Tatar & Krzysztof Świerzy & Michał Błachut & Karina Badura Brzoza, 2022. "Psychotic Disorders in the Course of SARS-CoV-2 Infection or Uncomplicated Amantadine Treatment?—Case Report," IJERPH, MDPI, vol. 19(23), pages 1-7, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15768-:d:985420
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    References listed on IDEAS

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    1. Gwenaëlle Douaud & Soojin Lee & Fidel Alfaro-Almagro & Christoph Arthofer & Chaoyue Wang & Paul McCarthy & Frederik Lange & Jesper L. R. Andersson & Ludovica Griffanti & Eugene Duff & Saad Jbabdi & Be, 2022. "SARS-CoV-2 is associated with changes in brain structure in UK Biobank," Nature, Nature, vol. 604(7907), pages 697-707, April.
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