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The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Author

Listed:
  • Jing-Xing Li

    (Department of General Medicine, China Medical University Hospital, Taichung 404327, Taiwan
    School of Medicine, China Medical University, Taichung 404328, Taiwan
    Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei 116216, Taiwan)

  • Chun-Chi Chiang

    (School of Medicine, China Medical University, Taichung 404328, Taiwan
    Department of Ophthalmology, China Medical University Hospital, Taichung 404327, Taiwan
    Department of Optometry, Asia University, Taichung 413305, Taiwan)

  • San-Ni Chen

    (Department of Ophthalmology, China Medical University Hospital, Taichung 404327, Taiwan
    School of Medicine, National Taiwan University, Taipei 116216, Taiwan)

  • Jane-Ming Lin

    (Department of Ophthalmology, China Medical University Hospital, Taichung 404327, Taiwan
    School of Chinese Medicine, China Medical University, Taichung 404328, Taiwan)

  • Yi-Yu Tsai

    (School of Medicine, China Medical University, Taichung 404328, Taiwan
    Department of Ophthalmology, China Medical University Hospital, Taichung 404327, Taiwan
    Department of Optometry, Asia University, Taichung 413305, Taiwan)

Abstract

Patients with inflammatory bowel disease (IBD) have a greater frequency of ocular extra-intestinal manifestations (O-EIMs) than the general population, while Crohn’s disease (CD) and ulcerative colitis (UC) have inconsistent prevalence, according to previous studies. This study aimed to examine the prevalence of O-EIMs in CD and UC, respectively. We systemically reviewed O-EIMs and IBD across several online databases. Inclusion criteria are as follows: (1) observational studies examining the association between O-EIMs and IBD, such as cross-sectional, case–control, or cohort studies; (2) human and adult individuals; and (3) with case and control groups consisting of patients with and without O-EIMs, respectively. Patients under the age of 18 or any study on pediatric IBD will be excluded. The prevalence of uveitis in adults was determined by 21 studies comprising 190,941 individuals with IBD, including 62,874 CD and 128,067 UC. The pooled analysis revealed significantly increased odds of uveitis in patients with CD than with UC (pooled odd ratio (OR) 1.603, 95% confidence interval 1.254–2.049). The subgroup analysis revealed that European populations had significantly higher odds of developing uveitis and episcleritis in patients with CD than UC (pooled OR 1.683 and 2.401, respectively). Although O-EIMs may be the prodrome of IBD, no consistent finding was obtained as a result of the high heterogeneity from the two included studies. This meta-analysis indicates the significantly increased odds of uveitis in adults with CD than those with UC. In subgroup analysis, European with CD seemed to have higher odds of uveitis and episcleritis than those with UC. Nonetheless, the link between O-EIMs and IBD remained unclear.

Suggested Citation

  • Jing-Xing Li & Chun-Chi Chiang & San-Ni Chen & Jane-Ming Lin & Yi-Yu Tsai, 2022. "The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-14, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:23:p:15683-:d:983996
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    References listed on IDEAS

    as
    1. Bo Ram Yang & Nam-Kyong Choi & Mi-Sook Kim & Jaeyoung Chun & Sang Hyun Joo & Hyesung Kim & Joongyub Lee, 2018. "Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-13, July.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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