IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i21p13996-d955157.html
   My bibliography  Save this article

Sodium Nitrite Intoxication and Death: Summarizing Evidence to Facilitate Diagnosis

Author

Listed:
  • Martina Padovano

    (Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy)

  • Mariarosaria Aromatario

    (Unit of Risk Management, Quality, and Accreditation, Sant’Andrea University Hospital, 00189 Rome, Italy)

  • Stefano D’Errico

    (Department of Medicine, Surgery and Health, University of Trieste, 34137 Trieste, Italy)

  • Monica Concato

    (Department of Medicine, Surgery and Health, University of Trieste, 34137 Trieste, Italy)

  • Federico Manetti

    (Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy)

  • Maria Chiara David

    (Department of Public Security, Health Central Directorate, Research Center and Forensic Toxicology Laboratory, Ministry of the Interior, 00184 Rome, Italy)

  • Matteo Scopetti

    (Department of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy)

  • Paola Frati

    (Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy)

  • Vittorio Fineschi

    (Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy)

Abstract

Background: Over the years, forensic pathology has registered the spread of new methods of suicide, such as the ingestion of sodium nitrite. Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death. The present review is aimed at guiding health professionals in the identification and management of sodium-nitrite-related intoxications and deaths. Methods: A systematic literature search was carried out on PubMed by following the PRISMA statement’s criteria. A total of 35 studies with 132 cases were enrolled, and the data were cataloged in Microsoft Excel. To establish the causal correlation between sodium nitrite ingestion and death, the Naranjo Adverse Drug Reaction Probability Scale was used. Results: In addition to the small number of cases that have currently been published, the study demonstrated that there was a general methodological discrepancy in the diagnostic process. However, some interesting results have emerged, especially in post-mortem diagnostics. Conclusion: Sodium-nitrite-related deaths represent a challenge for forensic pathologists; therefore, it is important to promptly recognize the essential features and perform the necessary and unrepeatable examinations for the correct diagnosis of the cause of death.

Suggested Citation

  • Martina Padovano & Mariarosaria Aromatario & Stefano D’Errico & Monica Concato & Federico Manetti & Maria Chiara David & Matteo Scopetti & Paola Frati & Vittorio Fineschi, 2022. "Sodium Nitrite Intoxication and Death: Summarizing Evidence to Facilitate Diagnosis," IJERPH, MDPI, vol. 19(21), pages 1-16, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:13996-:d:955157
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/21/13996/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/21/13996/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Joana M. Barros & Ruth Melia & Kady Francis & John Bogue & Mary O’Sullivan & Karen Young & Rebecca A. Bernert & Dietrich Rebholz-Schuhmann & Jim Duggan, 2019. "The Validity of Google Trends Search Volumes for Behavioral Forecasting of National Suicide Rates in Ireland," IJERPH, MDPI, vol. 16(17), pages 1-18, September.
    2. Roland Mergl & Nicole Koburger & Katherina Heinrichs & András Székely & Mónika Ditta Tóth & James Coyne & Sónia Quintão & Ella Arensman & Claire Coffey & Margaret Maxwell & Airi Värnik & Chantal van A, 2015. "What Are Reasons for the Large Gender Differences in the Lethality of Suicidal Acts? An Epidemiological Analysis in Four European Countries," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-18, July.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    4. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alessandro Concari & Gerjo Kok & Pim Martens, 2020. "A Systematic Literature Review of Concepts and Factors Related to Pro-Environmental Consumer Behaviour in Relation to Waste Management Through an Interdisciplinary Approach," Sustainability, MDPI, vol. 12(11), pages 1-50, May.
    2. Giuseppe La Torre & Remigio Bova & Rosario Andrea Cocchiara & Cristina Sestili & Anna Tagliaferri & Simona Maggiacomo & Camilla Foschi & William Zomparelli & Maria Vittoria Manai & David Shaholli & Va, 2023. "What Are the Determinants of the Quality of Systematic Reviews in the International Journals of Occupational Medicine? A Methodological Study Review of Published Literature," IJERPH, MDPI, vol. 20(2), pages 1-12, January.
    3. Frank Peinemann & Ulrich Grouven & Nicolaus Kröger & Carmen Bartel & Max H Pittler & Stefan Lange, 2011. "First-Line Matched Related Donor Hematopoietic Stem Cell Transplantation Compared to Immunosuppressive Therapy in Acquired Severe Aplastic Anemia," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-16, April.
    4. Jonathan Kingsley & Aisling Bailey & Nooshin Torabi & Pauline Zardo & Suzanne Mavoa & Tonia Gray & Danielle Tracey & Philip Pettitt & Nicholas Zajac & Emily Foenander, 2019. "A Systematic Review Protocol Investigating Community Gardening Impact Measures," IJERPH, MDPI, vol. 16(18), pages 1-12, September.
    5. Ferrán Catalá-López & Adolfo Alonso-Arroyo & Matthew J Page & Brian Hutton & Rafael Tabarés-Seisdedos & Rafael Aleixandre-Benavent, 2018. "Mapping of global scientific research in comorbidity and multimorbidity: A cross-sectional analysis," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-24, January.
    6. Tobias Elze, 2010. "Misspecifications of Stimulus Presentation Durations in Experimental Psychology: A Systematic Review of the Psychophysics Literature," PLOS ONE, Public Library of Science, vol. 5(9), pages 1-7, September.
    7. S. Rajsic & H. Gothe & H. H. Borba & G. Sroczynski & J. Vujicic & T. Toell & Uwe Siebert, 2019. "Economic burden of stroke: a systematic review on post-stroke care," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(1), pages 107-134, February.
    8. Sibonokuhle Ndlovu, 2023. "Preparedness and Response to COVID-19 Disruptions and Learning Challenges for Students with Disabilities in South Africa: A Systematic Review," Sustainability, MDPI, vol. 15(2), pages 1-17, January.
    9. Abbas Mardani & Dalia Streimikiene & Edmundas Kazimieras Zavadskas & Fausto Cavallaro & Mehrbakhsh Nilashi & Ahmad Jusoh & Habib Zare, 2017. "Application of Structural Equation Modeling (SEM) to Solve Environmental Sustainability Problems: A Comprehensive Review and Meta-Analysis," Sustainability, MDPI, vol. 9(10), pages 1-65, October.
    10. Luísa Bandeira Lopes & João Albernaz Neves & João Botelho & Vanessa Machado & José João Mendes, 2021. "Regenerative Endodontic Procedures: An Umbrella Review," IJERPH, MDPI, vol. 18(2), pages 1-17, January.
    11. Gaspar, Rui & Yan, Zheng & Domingos, Samuel, 2019. "Extreme natural and man-made events and human adaptive responses mediated by information and communication technologies' use: A systematic literature review," Technological Forecasting and Social Change, Elsevier, vol. 145(C), pages 125-135.
    12. Nicholas A. Kirk & Nicholas A. Cradock-Henry, 2022. "Land Management Change as Adaptation to Climate and Other Stressors: A Systematic Review of Decision Contexts Using Values-Rules-Knowledge," Land, MDPI, vol. 11(6), pages 1-23, May.
    13. Timothy Noblet & John Marriott & Emma Graham-Clarke & Debra Shirley & Alison Rushton, 2018. "Clinical and cost-effectiveness of non-medical prescribing: A systematic review of randomised controlled trials," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-15, March.
    14. Abbas Mardani & Mehrbakhsh Nilashi & Jurgita Antucheviciene & Madjid Tavana & Romualdas Bausys & Othman Ibrahim, 2017. "Recent Fuzzy Generalisations of Rough Sets Theory: A Systematic Review and Methodological Critique of the Literature," Complexity, Hindawi, vol. 2017, pages 1-33, October.
    15. Wen-Hsiu Yeh & Ya-Ju Ju & Yu-Ting Liu & Ting-Yi Wang, 2022. "Systematic Review and Meta-Analysis on the Effects of Neurofeedback Training of Theta Activity on Working Memory and Episodic Memory in Healthy Population," IJERPH, MDPI, vol. 19(17), pages 1-14, September.
    16. Gourzoulidis, George & Kourlaba, Georgia & Stafylas, Panagiotis & Giamouzis, Gregory & Parissis, John & Maniadakis, Nikolaos, 2017. "Association between copayment, medication adherence and outcomes in the management of patients with diabetes and heart failure," Health Policy, Elsevier, vol. 121(4), pages 363-377.
    17. Cristina Chifor & Iulia D. Arion & Vlad I. Isarie & Felix H. Arion, 2022. "A Systematic Literature Review on European Food Quality Schemes in Romania," Sustainability, MDPI, vol. 14(23), pages 1-16, December.
    18. Snyder, Hannah, 2019. "Literature review as a research methodology: An overview and guidelines," Journal of Business Research, Elsevier, vol. 104(C), pages 333-339.
    19. Pineros-Leano, María & Parchment, Tyrone M. & Calvo, Rocío, 2023. "Family interventions to improve mental, emotional, and behavioral health outcomes among Latinx youth: A systematic review," Children and Youth Services Review, Elsevier, vol. 145(C).
    20. Teresa Loda & Rebecca Erschens & Hannah Loenneker & Katharina E Keifenheim & Christoph Nikendei & Florian Junne & Stephan Zipfel & Anne Herrmann-Werner, 2019. "Cognitive and social congruence in peer-assisted learning – A scoping review," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-15, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:13996-:d:955157. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.