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Impacts of Astaxanthin Supplementation on Walking Capacity by Reducing Oxidative Stress in Nursing Home Residents

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  • Ryosuke Nakanishi

    (Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan
    Department of Physical Therapy, Kobe International University, Kobe 658-0032, Japan
    These authors contributed equally to this work.)

  • Miho Kanazashi

    (Department of Physical Therapy, Prefectural University of Hiroshima, Hiroshima 723-0053, Japan
    These authors contributed equally to this work.)

  • Masayuki Tanaka

    (Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan
    Department of Physical Therapy, Okayama Healthcare Professional University, Okayama 700-0913, Japan)

  • Minoru Tanaka

    (Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan
    Department of Rehabilitation Science, Osaka Health Science University, Osaka 530-0043, Japan)

  • Hidemi Fujino

    (Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe 654-0142, Japan)

Abstract

Oxidative stress is associated with deterioration of endurance and muscle strength, which are mostly accompanied by aging. Astaxanthin supplement has excellent antioxidant activity without any pro-oxidative properties. In this study, we investigated how astaxanthin supplementation affects walking endurance and muscle strength in nursing home residents. Healthy elderly individuals (age: 67 to 94) were divided into two groups: 13 subjects received a daily dose of 24 mg of astaxanthin for 16 weeks (astaxanthin group) and 11 subjects received a placebo (placebo group). These subjects were compared using body component measurements, serum d-ROM levels, the distance of 6-min walking, blood lactate levels after the 6-min walking test, and muscle strength. After supplementation, the levels of d-ROMs and blood lactate after the 6-min walking test in the astaxanthin group significantly decreased compared with the placebo group ( p < 0.05). Additionally, the walking distance was significantly higher in the astaxanthin group than in the placebo group ( p < 0.05), despite a significant reduction in lactate levels after 6-MWT ( p < 0.05). However, no significant intergroup differences were observed in muscle mass and strength. Astaxanthin supplement for 16 weeks is effective to increase the endurance capacity of the elderly. Astaxanthin supplement suppresses d-ROMs at rest and lactic acid production after the 6-min walk test. In contrast, astaxanthin supplement did not show significant intergroup differences in the muscle mass and strength. Therefore, the effect was most likely accompanied by an increase in endurance instead of an increase in muscle strength.

Suggested Citation

  • Ryosuke Nakanishi & Miho Kanazashi & Masayuki Tanaka & Minoru Tanaka & Hidemi Fujino, 2022. "Impacts of Astaxanthin Supplementation on Walking Capacity by Reducing Oxidative Stress in Nursing Home Residents," IJERPH, MDPI, vol. 19(20), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:20:p:13492-:d:946314
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    References listed on IDEAS

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    1. Hayek, F. A., 2012. "Hayek on Hayek," University of Chicago Press Economics Books, University of Chicago Press, edition 1, number 9780226321202 edited by Kresge, Stephen & Wenar, Leif, December.
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