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Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study

Author

Listed:
  • Hokuto Nakata

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
    These authors contributed equally to this work.)

  • Akifumi Eguchi

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan
    These authors contributed equally to this work.)

  • Shouta M. M. Nakayama

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan)

  • John Yabe

    (School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia
    School of Veterinary Medicine, University of Namibia, P/B. 13301, Windhoek 10005, Namibia)

  • Kaampwe Muzandu

    (School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia)

  • Yoshinori Ikenaka

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan
    Water Research Group, School of Environmental Sciences and Development, North-West University, Private Bag X6001, Potchefstroom 2531, South Africa
    Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    One Health Research Center, Hokkaido University, Sapporo 060-0818, Japan)

  • Chisato Mori

    (Center for Preventive Medical Sciences, Chiba University, Inage-ku Yayoi-cho 1-33, Chiba 263-8522, Japan
    Department of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chuo-ku Inohana 1-8-1, Chiba 260-8670, Japan)

  • Mayumi Ishizuka

    (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo 060-0818, Japan)

Abstract

Lead poisoning is often considered a traditional disease; however, the specific mechanism of toxicity remains unclear. The study of Pb-induced alterations in cellular metabolic pathways is important to understand the biological response and disorders associated with environmental exposure to lead. Metabolomics studies have recently been paid considerable attention to understand in detail the biological response to lead exposure and the associated toxicity mechanisms. In the present study, wild rodents collected from an area contaminated with lead (N = 18) and a control area (N = 10) were investigated. This was the first ever experimental metabolomic study of wildlife exposed to lead in the field. While the levels of plasma phenylalanine and isoleucine were significantly higher in a lead-contaminated area versus the control area, hydroxybutyric acid was marginally significantly higher in the contaminated area, suggesting the possibility of enhancement of lipid metabolism. In the interregional least-absolute shrinkage and selection operator (lasso) regression model analysis, phenylalanine and isoleucine were identified as possible biomarkers, which is in agreement with the random forest model. In addition, in the random forest model, glutaric acid, glutamine, and hydroxybutyric acid were selected. In agreement with previous studies, enrichment analysis showed alterations in the urea cycle and ATP-binding cassette transporter pathways. Although regional rodent species bias was observed in this study, and the relatively small sample size should be taken into account, the present results are to some extent consistent with those of previous studies on humans and laboratory animals.

Suggested Citation

  • Hokuto Nakata & Akifumi Eguchi & Shouta M. M. Nakayama & John Yabe & Kaampwe Muzandu & Yoshinori Ikenaka & Chisato Mori & Mayumi Ishizuka, 2022. "Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study," IJERPH, MDPI, vol. 19(1), pages 1-14, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:1:p:541-:d:717372
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    References listed on IDEAS

    as
    1. Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2010. "Regularization Paths for Generalized Linear Models via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 33(i01).
    2. Kuhn, Max, 2008. "Building Predictive Models in R Using the caret Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 28(i05).
    3. Andrew Kataba & Shouta M. M. Nakayama & Hokuto Nakata & Haruya Toyomaki & Yared B. Yohannes & John Yabe & Kaampwe Muzandu & Golden Zyambo & Ayano Kubota & Takehisa Matsukawa & Kazuhito Yokoyama & Yosh, 2021. "An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS," IJERPH, MDPI, vol. 18(2), pages 1-15, January.
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