IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i19p12615-d932171.html
   My bibliography  Save this article

A Comprehensive Review on Multifaceted Mechanisms Involved in the Development of Breast Cancer Following Adverse Childhood Experiences (ACEs)

Author

Listed:
  • Olimpia Pino

    (Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy)

  • Rosalinda Trevino Cadena

    (Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy)

  • Diana Poli

    (INAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene Via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

Abstract

Background and aim of the work. Adverse Childhood Experiences (ACEs) may give rise to harmful effects on health throughout life. Epigenetic changes explain how preexisting risk factors may contribute to produce altered biological responses and cancer risk. The main aim of the review is to summarize studies examining the means in which Adverse Childhood Experiences (ACEs) can modulate individual vulnerability to breast cancer (BC) development through multifaceted mechanisms. Methods. Studies selection, data extraction, and assessments agreed to PRISMA criteria. We included original research with clinical samples following BC interventions, investigating potential mechanisms linking ACEs and BC in adults. Results. From the 3321 papers found, nine articles involving 2931 participants were selected. All studies included ACEs retrospective assessments and psychological measures, and seven of them considered biomarkers. Individuals exposed to greater ACEs were at increased BC risk compared with individuals with no ACEs. Associations were found between child abuse and/or neglect, depression, perceived stress, fatigue, and plasma levels of cytokines interleukin (IL-6), C-reactive protein (CRP), soluble tumor necrosis factor receptor type II (sTNF-RII), interleukin IL-1 receptor antagonist (IL-1ra), and psycho-physiological adjustments that may lead to BC. Conclusions. Exposure to multiple ACEs appears a risk factor for BC development in adulthood. Although the clinical relevance of findings such as this is ambiguous, the review added evidence for a link between the presence of childhood adversity and BC occurrence, pointing to psychological, hormonal, and immunological dysregulations.

Suggested Citation

  • Olimpia Pino & Rosalinda Trevino Cadena & Diana Poli, 2022. "A Comprehensive Review on Multifaceted Mechanisms Involved in the Development of Breast Cancer Following Adverse Childhood Experiences (ACEs)," IJERPH, MDPI, vol. 19(19), pages 1-19, October.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12615-:d:932171
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/19/12615/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/19/12615/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Morton, Patricia M. & Mustillo, Sarah A. & Ferraro, Kenneth F., 2014. "Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?," Social Science & Medicine, Elsevier, vol. 104(C), pages 133-141.
    2. Rosana E Norman & Munkhtsetseg Byambaa & Rumna De & Alexander Butchart & James Scott & Theo Vos, 2012. "The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis," PLOS Medicine, Public Library of Science, vol. 9(11), pages 1-31, November.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    4. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    5. Levine, M.E. & Cole, S.W. & Weir, D.R. & Crimmins, E.M., 2015. "Childhood and later life stressors and increased inflammatory gene expression at older ages," Social Science & Medicine, Elsevier, vol. 130(C), pages 16-22.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Elizabeth T Cafiero-Fonseca & Andrew Stawasz & Sydney T Johnson & Reiko Sato & David E Bloom, 2017. "The full benefits of adult pneumococcal vaccination: A systematic review," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-23, October.
    2. Su Keng Tan & Wai Keung Leung & Alexander Tin Hong Tang & Roger A Zwahlen, 2017. "Effects of mandibular setback with or without maxillary advancement osteotomies on pharyngeal airways: An overview of systematic reviews," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-20, October.
    3. Alessandro Concari & Gerjo Kok & Pim Martens, 2020. "A Systematic Literature Review of Concepts and Factors Related to Pro-Environmental Consumer Behaviour in Relation to Waste Management Through an Interdisciplinary Approach," Sustainability, MDPI, vol. 12(11), pages 1-50, May.
    4. Jacob Elnaggar & Fern Tsien & Lucio Miele & Chindo Hicks & Clayton Yates & Melisa Davis, 2019. "An Integrative Genomics Approach for Associating Genetic Susceptibility with the Tumor Immune Microenvironment in Triple Negative Breast Cancer," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 15(1), pages 1-12, February.
    5. Hyun Kim & Navneet Kaur Baidwan & David Kriebel & Manuel Cifuentes & Sherry Baron, 2018. "Asthma among World Trade Center First Responders: A Qualitative Synthesis and Bias Assessment," IJERPH, MDPI, vol. 15(6), pages 1-14, May.
    6. Giuseppe La Torre & Remigio Bova & Rosario Andrea Cocchiara & Cristina Sestili & Anna Tagliaferri & Simona Maggiacomo & Camilla Foschi & William Zomparelli & Maria Vittoria Manai & David Shaholli & Va, 2023. "What Are the Determinants of the Quality of Systematic Reviews in the International Journals of Occupational Medicine? A Methodological Study Review of Published Literature," IJERPH, MDPI, vol. 20(2), pages 1-12, January.
    7. Frank Peinemann & Ulrich Grouven & Nicolaus Kröger & Carmen Bartel & Max H Pittler & Stefan Lange, 2011. "First-Line Matched Related Donor Hematopoietic Stem Cell Transplantation Compared to Immunosuppressive Therapy in Acquired Severe Aplastic Anemia," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-16, April.
    8. Jonathan Kingsley & Aisling Bailey & Nooshin Torabi & Pauline Zardo & Suzanne Mavoa & Tonia Gray & Danielle Tracey & Philip Pettitt & Nicholas Zajac & Emily Foenander, 2019. "A Systematic Review Protocol Investigating Community Gardening Impact Measures," IJERPH, MDPI, vol. 16(18), pages 1-12, September.
    9. Wei-Wei Chen & Feng Wang & Rui-Hua Xu, 2013. "Platinum-Based Versus Non-Platinum-Based Chemotherapy as First Line Treatment of Inoperable, Advanced Gastric Adenocarcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
    10. Giovanni Vinti & Valerie Bauza & Thomas Clasen & Kate Medlicott & Terry Tudor & Christian Zurbrügg & Mentore Vaccari, 2021. "Municipal Solid Waste Management and Adverse Health Outcomes: A Systematic Review," IJERPH, MDPI, vol. 18(8), pages 1-26, April.
    11. Hanna Górska-Warsewicz, 2022. "Consumer or Patient Determinants of Hospital Brand Equity—A Systematic Literature Review," IJERPH, MDPI, vol. 19(15), pages 1-36, July.
    12. André Ramalho & João Serrano & Rui Paulo & Pedro Duarte-Mendes & António Rosado & João Petrica, 2021. "Emerging Qualitative Research Trends (2010–2021) on Sedentary Behaviour among Older Adults: A Systematic Literature Review Protocol," IJERPH, MDPI, vol. 18(21), pages 1-8, November.
    13. S. Rajsic & H. Gothe & H. H. Borba & G. Sroczynski & J. Vujicic & T. Toell & Uwe Siebert, 2019. "Economic burden of stroke: a systematic review on post-stroke care," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(1), pages 107-134, February.
    14. Sibonokuhle Ndlovu, 2023. "Preparedness and Response to COVID-19 Disruptions and Learning Challenges for Students with Disabilities in South Africa: A Systematic Review," Sustainability, MDPI, vol. 15(2), pages 1-17, January.
    15. João Carlos Belloti & Aldo Okamura & Jordana Scheeren & Flávio Faloppa & Vinícius Ynoe de Moraes, 2019. "A systematic review of the quality of distal radius systematic reviews: Methodology and reporting assessment," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-12, January.
    16. Abbas Mardani & Dalia Streimikiene & Edmundas Kazimieras Zavadskas & Fausto Cavallaro & Mehrbakhsh Nilashi & Ahmad Jusoh & Habib Zare, 2017. "Application of Structural Equation Modeling (SEM) to Solve Environmental Sustainability Problems: A Comprehensive Review and Meta-Analysis," Sustainability, MDPI, vol. 9(10), pages 1-65, October.
    17. Luísa Bandeira Lopes & João Albernaz Neves & João Botelho & Vanessa Machado & José João Mendes, 2021. "Regenerative Endodontic Procedures: An Umbrella Review," IJERPH, MDPI, vol. 18(2), pages 1-17, January.
    18. Gaspar, Rui & Yan, Zheng & Domingos, Samuel, 2019. "Extreme natural and man-made events and human adaptive responses mediated by information and communication technologies' use: A systematic literature review," Technological Forecasting and Social Change, Elsevier, vol. 145(C), pages 125-135.
    19. Nicholas A. Kirk & Nicholas A. Cradock-Henry, 2022. "Land Management Change as Adaptation to Climate and Other Stressors: A Systematic Review of Decision Contexts Using Values-Rules-Knowledge," Land, MDPI, vol. 11(6), pages 1-23, May.
    20. Timothy Noblet & John Marriott & Emma Graham-Clarke & Debra Shirley & Alison Rushton, 2018. "Clinical and cost-effectiveness of non-medical prescribing: A systematic review of randomised controlled trials," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-15, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12615-:d:932171. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.