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Medication Non-Adherence in Rheumatology, Oncology and Cardiology: A Review of the Literature of Risk Factors and Potential Interventions

Author

Listed:
  • Vicente F. Gil-Guillen

    (Department of Clinical Medicine, Miguel Hernandez University, 03550 San Juan, Spain
    Research Unit, Hospital General Universitario de Elda, 30600 Elda, Spain)

  • Alejandro Balsa

    (Rheumatology Department, La Paz University Hospital, 28046 Madrid, Spain
    Institute for Health Research Hospital La Paz (IdiPaz), 28046 Madrid, Spain)

  • Beatriz Bernárdez

    (Department of Oncologic Pharmacy, Santiago de Compostela University Hospital, 15706 Santiago de Compostela, Spain
    Medicine Department, Santiago de Compostela University, 15706 Santiago de Compostela, Spain
    Pharmacology Group, Health Research Institute of Santiago de Compostela (IDIS), 15782 Santiago de Compostela, Spain
    Adherence Group of the Sociedad Española de Farmacia Hospitalaria (ADHEFAR-SEFH), 28001 Madrid, Spain)

  • Carmen Valdés y Llorca

    (Fuencarral Health Center, 28034 Madrid, Spain
    Observatorio de Adherencia al Tratamiento (OAT), 28231 Madrid, Spain
    Treatment Adherence Chair, San Juan de Alicante University, 03550 Alicante, Spain)

  • Emilio Márquez-Contreras

    (Molino de la Vega Health Center, 21002 Huelva, Spain)

  • Juan de la Haba-Rodríguez

    (The Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Cordoba, Spain)

  • Jose M. Castellano

    (Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain
    Centro Integral de Enfermedades Cardiovasculares, Monteprincipe University Hospital, 28660 Madrid, Spain)

  • Jesús Gómez-Martínez

    (Communiy Pharmacist, 08013 Barcelona, Spain)

Abstract

Medication adherence is directly associated with health outcomes. Adherence has been reviewed extensively; however, most studies provide a narrow scope of the problem, covering a specific disease or treatment. This project’s objective was to identify risk factors for non-adherence in the fields of rheumatology, oncology, and cardiology as well as potential interventions to improve adherence and their association with the risk factors. The project was developed in three phases and carried out by a Steering Committee made up of experts from the fields of rheumatology, oncology, cardiology, general medicine, and hospital and community pharmacy. In phase 1, a bibliographic review was performed, and the articles/reviews were classified according to the authors’ level of confidence in the results and their clinical relevance. In phase 2, 20 risk factors for non-adherence were identified from these articles/reviews and agreed upon in Steering Committee meetings. In phase 3, potential interventions for improving adherence were also identified and agreed upon. The results obtained show that adherence is a dynamic concept that can change throughout the course of the disease, the treatments, and other factors. Educational interventions are the most studied ones and have the highest level of confidence in the authors’ opinion. Information and education are essential to improve adherence in all patients.

Suggested Citation

  • Vicente F. Gil-Guillen & Alejandro Balsa & Beatriz Bernárdez & Carmen Valdés y Llorca & Emilio Márquez-Contreras & Juan de la Haba-Rodríguez & Jose M. Castellano & Jesús Gómez-Martínez, 2022. "Medication Non-Adherence in Rheumatology, Oncology and Cardiology: A Review of the Literature of Risk Factors and Potential Interventions," IJERPH, MDPI, vol. 19(19), pages 1-23, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:19:p:12036-:d:923036
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    References listed on IDEAS

    as
    1. Theodore Darkow & Henry Henk & Simu Thomas & Weiwei Feng & Jean-Francois Baladi & George Goldberg & Alan Hatfield & Jorge Cortes, 2007. "Treatment Interruptions and Non-Adherence with Imatinib and Associated Healthcare Costs," PharmacoEconomics, Springer, vol. 25(6), pages 481-496, June.
    2. Chan, David Chimin & Avorn, Jerry Lewis & Solomon, Daniel Hal & Brookhart, Alan & Choudhry, Niteesh K & Cutler, David M. & Jan, Saira & Fischer, Michael Adam & Liu, Jun & Shrank, William H., 2010. "Patient, Physician, and Payment Predictors of Statin Adherence," Scholarly Articles 5343023, Harvard University Department of Economics.
    3. Kun-Pin Hsieh & Li-Chia Chen & Kwok-Leung Cheung & Chao-Sung Chang & Yi-Hsin Yang, 2014. "Interruption and Non-Adherence to Long-Term Adjuvant Hormone Therapy Is Associated with Adverse Survival Outcome of Breast Cancer Women - An Asian Population-Based Study," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    4. Linda Campbell & Caroline Masquillier & Estrelle Thunnissen & Esther Ariyo & Hanani Tabana & Neo Sematlane & Anton Delport & Lorraine Tanyaradzwa Dube & Lucia Knight & Tair Kasztan Flechner & Edwin Wo, 2020. "Social and Structural Determinants of Household Support for ART Adherence in Low- and Middle-Income Countries: A Systematic Review," IJERPH, MDPI, vol. 17(11), pages 1-28, May.
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