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Interruption and Non-Adherence to Long-Term Adjuvant Hormone Therapy Is Associated with Adverse Survival Outcome of Breast Cancer Women - An Asian Population-Based Study

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  • Kun-Pin Hsieh
  • Li-Chia Chen
  • Kwok-Leung Cheung
  • Chao-Sung Chang
  • Yi-Hsin Yang

Abstract

This study aimed to evaluate the survival rate of women with breast cancer (BC) comparing persistence versus interruption and adherence versus non-adherence to adjuvant hormonal therapy (HT) in Asian population. Newly-diagnosed BC women from 2003 to 2010 were retrospectively identified from the Taiwan National Health Insurance Research Database. HT prescriptions were extracted to define treatment interruption and medication possession ratio. Their impacts on mortality were estimated by Cox regression with time dependent covariates. Interruption (HR: 1.32; 95% CI: 1.20, 1.46; P

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  • Kun-Pin Hsieh & Li-Chia Chen & Kwok-Leung Cheung & Chao-Sung Chang & Yi-Hsin Yang, 2014. "Interruption and Non-Adherence to Long-Term Adjuvant Hormone Therapy Is Associated with Adverse Survival Outcome of Breast Cancer Women - An Asian Population-Based Study," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-9, February.
    • Handle: RePEc:plo:pone00:0087027
    DOI: 10.1371/journal.pone.0087027
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    Cited by:

    1. Vicente F. Gil-Guillen & Alejandro Balsa & Beatriz Bernárdez & Carmen Valdés y Llorca & Emilio Márquez-Contreras & Juan de la Haba-Rodríguez & Jose M. Castellano & Jesús Gómez-Martínez, 2022. "Medication Non-Adherence in Rheumatology, Oncology and Cardiology: A Review of the Literature of Risk Factors and Potential Interventions," IJERPH, MDPI, vol. 19(19), pages 1-23, September.

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