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Association of Metabolically Healthy Obesity and Glomerular Filtration Rate among Male Steelworkers in North China

Author

Listed:
  • Miao Yu

    (Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China
    These authors contributed equally to this work.)

  • Shengkui Zhang

    (Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical, Beijing 100005, China
    These authors contributed equally to this work.)

  • Lihua Wang

    (Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China)

  • Hongman Feng

    (Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China)

  • Xiaoming Li

    (Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China)

  • Jianhui Wu

    (Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China)

  • Juxiang Yuan

    (Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Tangshan 063210, China)

Abstract

This study aims to investigate the association between metabolically healthy obesity (MHO) and the early stages of renal dysfunction and whether systemic inflammation affects the study’s outcome. Male steelworkers in northern China were investigated in this cross-sectional survey ( n = 6309). A decrease in estimated glomerular filtration rate (eGFR) was used as the primary outcome, which was defined as an eGFR of ≤89 mL/min/1.73 m 2 . A BMI ≥ 25 kg/m 2 was used to determine obesity. In the definition of metabolic health, the absence of metabolic syndrome components is considered metabolically healthy. An assessment of inflammation was carried out using a surrogate marker called high-sensitivity C-reactive protein (hs-CRP). The adjusted odds ratio (OR) and confidence intervals (CIs) were estimated using the multivariable logistic regression model. After adjusting for hs-CRP, MHO (OR = 1.97; 95% CI: 1.21 to 3.21) was significantly associated with decreased eGFR compared to metabolically healthy non-obesity (MHNO). With the MHNO/hs-CRP ≤ 0.01 mg/dL group as a reference, the OR was 2.17 (95% CI: 1.17 to 4.02) for decreased eGFR in the group with MHO/hs-CRP > 0.01 mg/dL. MHO is associated with renal dysfunction at an early stage. To some degree, this risk can be explained by the level of inflammation.

Suggested Citation

  • Miao Yu & Shengkui Zhang & Lihua Wang & Hongman Feng & Xiaoming Li & Jianhui Wu & Juxiang Yuan, 2022. "Association of Metabolically Healthy Obesity and Glomerular Filtration Rate among Male Steelworkers in North China," IJERPH, MDPI, vol. 19(18), pages 1-9, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11764-:d:917902
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    References listed on IDEAS

    as
    1. Shengkui Zhang & Yongbin Wang & Ying Zhu & Xiaoming Li & Yang Song & Juxiang Yuan, 2020. "Rotating Night Shift Work, Exposure to Light at Night, and Glomerular Filtration Rate: Baseline Results from a Chinese Occupational Cohort," IJERPH, MDPI, vol. 17(23), pages 1-14, December.
    2. Fatima Nari & Bich Na Jang & Gyu Ri Kim & Eun-Cheol Park & Sung-In Jang, 2020. "Synergistic Effects and Sex Differences in Anthropometric Measures of Obesity and Elevated High-Sensitivity C-Reactive Protein Levels," IJERPH, MDPI, vol. 17(21), pages 1-11, November.
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