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Higher Neutrophil-To-Lymphocyte Ratio Was Associated with Increased Risk of Chronic Kidney Disease in Overweight/Obese but Not Normal-Weight Individuals

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  • Chia-Ho Lin

    (Department of Medical Education, Taichung Veterans General Hospital, Taichung 40705, Taiwan)

  • Yu-Hsuan Li

    (Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan)

  • Ya-Yu Wang

    (Department of Family Medicine, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Section 4, Taichung 40705, Taiwan
    Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 402202, Taiwan
    School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan)

  • Wen-Dau Chang

    (Department of Family Medicine, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Section 4, Taichung 40705, Taiwan
    Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan)

Abstract

Background : Inflammation has been proposed to play potential roles in the development and progression of chronic kidney disease (CKD). We evaluated the relationship of neutrophil-to-lymphocyte ratio (NLR), a systemic inflammation marker, with CKD in normal-weight and overweight/obese adults. Methods : This cross-sectional study included 2846 apparently healthy adults who underwent a health examination between August 2000 and April 2002. Normal-weight was defined as a body mass index (BMI, kg/m 2 ) of 18.5–24, while overweight/obesity was defined as a BMI of ≥24. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m 2 . Logistic and linear regression analysis was performed to explore the NLR–CKD relationship. Results : Of the 2846 participants (1777 men and 1069 women), there were 348 CKD individuals (12.3%), with 262 (14.7%) men and 86 (8%) women. A total of 1011 men (56.9%) and 408 women (38.2%) were overweight or obese. Compared with the normal-weight participants, CKD prevalence was higher in the overweight/obese women (6.1% vs. 11.3%, p = 0.002), but not in the overweight/obese men (14.5% vs. 14.9%, p = 0.793). CKD percentages in the NLR quartile groups were 9.4%, 11.5%, 15.4%, and 22.7% in men ( p < 0.0001) and 6.4%, 7.1%, 10.5%, and 8.2% in women ( p = 0.2291). After adjustment for confounders, each increment of one unit of NLR was associated with a higher CKD risk in the overweight/obese men (adjusted odds ratio (OR) = 1.37, 95% confidence interval (CI) = 1.03–1.82, p = 0.03) and women (adjusted OR = 1.77, 95% CI = 1.08–2.90, p = 0.023), whereas NLR was not associated with CKD in normal-weight men or women. Further, in the overweight/obese participants with an eGFR of 50–70 mL/min/1.73 m 2 , univariable linear regression analysis revealed a significant negative correlation between NLR and eGFR for men ( p = 0.004) and women ( p = 0.009). Conclusions : It was found that higher NLR was associated with an increased CKD risk in overweight/obese but not in normal-weight men and women in an adult health examination dataset. Our study suggests a role of NLR for CKD prediction in overweight/obese individuals.

Suggested Citation

  • Chia-Ho Lin & Yu-Hsuan Li & Ya-Yu Wang & Wen-Dau Chang, 2022. "Higher Neutrophil-To-Lymphocyte Ratio Was Associated with Increased Risk of Chronic Kidney Disease in Overweight/Obese but Not Normal-Weight Individuals," IJERPH, MDPI, vol. 19(13), pages 1-13, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8077-:d:853381
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    References listed on IDEAS

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    1. Fatima Nari & Bich Na Jang & Gyu Ri Kim & Eun-Cheol Park & Sung-In Jang, 2020. "Synergistic Effects and Sex Differences in Anthropometric Measures of Obesity and Elevated High-Sensitivity C-Reactive Protein Levels," IJERPH, MDPI, vol. 17(21), pages 1-11, November.
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    Cited by:

    1. Szu-Ting Yang & Chia-Hao Liu & Sheng-Hsiang Ma & Wen-Hsun Chang & Yi-Jen Chen & Wen-Ling Lee & Peng-Hui Wang, 2022. "Association between Pre-Pregnancy Overweightness/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(15), pages 1-16, July.

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