IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i17p10482-d895237.html
   My bibliography  Save this article

Fetal Exposure to Air Pollution in Late Pregnancy Significantly Increases ADHD-Risk Behavior in Early Childhood

Author

Listed:
  • Binquan Liu

    (Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210006, China
    These authors contributed equally to this work.)

  • Xinyu Fang

    (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China
    Department of Public Health and Health Administration, Clincial College of Anhui Medical University, Hefei 230031, China
    Anhui Province Laboratory of Inflammation and Immune Mediated Disease, Hefei 230032, China
    These authors contributed equally to this work.)

  • Esben Strodl

    (School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD 4059, Australia)

  • Guanhao He

    (Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China)

  • Zengliang Ruan

    (Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China)

  • Ximeng Wang

    (Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China)

  • Li Liu

    (Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China)

  • Weiqing Chen

    (Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
    Department of Information Management, Xinhua College of Sun Yat-sen University, Guangzhou 510080, China)

Abstract

Background: Air pollution nowadays has seriously threatened the health of the Chinese population, especially in the vulnerable groups of fetuses, infants and toddlers. In particular, the effects of air pollution on children’s neurobehavioral development have attracted widespread attention. Moreover, the early detection of a sensitive period is very important for the precise intervention of the disease. However, such studies focusing on hyperactive behaviors and susceptible window identification are currently lacking in China. Objectives: The study aims to explore the correlation between air pollution exposure and hyperactive behaviors during the early life stage and attempt to identify whether a susceptible exposure window exists that is crucial for further precise intervention. Methods: Based on the Longhua Child Cohort Study, we collected the basic information and hyperactivity index of 26,052 children using a questionnaire conducted from 2015 to 2017, and the Conners’ Parent Rating Scale-revised (CPRS-48) was used to assess hyperactive behaviors. Moreover, the data of air pollution concentration (PM 10 , PM 2.5 , NO 2 , CO, O 3 and SO 2 ) were collected from the monitoring station between 2011 to 2017, and a land-use random forest model was used to evaluate the exposure level of each subject. Furthermore, Distributed lag non-linear models (DLNMs) were applied for statistic analysis. Results: The risk of child hyperactivity was found to be positively associated with early life exposure to PM 10 , PM 2.5 and NO 2 . In particular, for an increase of per 10 µg/m 3 in PM 10 , PM 2.5 and NO 2 exposure concentration during early life, the risk of child hyperactivity increased significantly during the seventh month of pregnancy to the fourth month after birth, with the strongest association in the ninth month of pregnancy (PM 10 : OR = 1.043, 95% CI: 1.016–1.071; PM 2.5 : OR = 1.062, 95% CI: 1.024–1.102; NO 2 : OR = 1.043, 95% CI: 1.016–1.071). However, no significant associations among early life exposure to CO, O 3 and SO 2 and child hyperactive behaviors were observed. Conclusions: Early life exposure to PM 10 , PM 2.5 and NO 2 is associated with an increased risk of child ADHD-like behaviors at the age around 3 years, and the late-prenatal and early postnatal periods might be the susceptible exposure windows.

Suggested Citation

  • Binquan Liu & Xinyu Fang & Esben Strodl & Guanhao He & Zengliang Ruan & Ximeng Wang & Li Liu & Weiqing Chen, 2022. "Fetal Exposure to Air Pollution in Late Pregnancy Significantly Increases ADHD-Risk Behavior in Early Childhood," IJERPH, MDPI, vol. 19(17), pages 1-16, August.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10482-:d:895237
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/17/10482/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/17/10482/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Qingmei Lin & Xiang-Yu Hou & Xiao-Na Yin & Guo-Min Wen & Dengli Sun & Dan-Xia Xian & Lijun Fan & Hui Jiang & Jin Jing & Yu Jin & Chuan-An Wu & Wei-Qing Chen, 2017. "Prenatal Exposure to Environmental Tobacco Smoke and Hyperactivity Behavior in Chinese Young Children," IJERPH, MDPI, vol. 14(10), pages 1-12, September.
    2. Guan-Hao He & Li Liu & Esben Strodl & Zeng-Liang Ruan & Hui Jiang & Jin Jing & Yu Jin & Wei-Qing Chen, 2019. "Parental Type D Personality and Children’s Hyperactive Behaviors: The Mediating Role of Parent–Child Interactive Activities," IJERPH, MDPI, vol. 16(7), pages 1-14, March.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sharanpreet Kaur & Paula Morales-Hidalgo & Victoria Arija & Josefa Canals, 2023. "Prenatal Exposure to Air Pollutants and Attentional Deficit Hyperactivity Disorder Development in Children: A Systematic Review," IJERPH, MDPI, vol. 20(8), pages 1-21, April.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lihua Huang & Gui-You Yang & Katrina L. Schmid & Jing-Yi Chen & Chen-Guang Li & Guan-Hao He & Zeng-Liang Ruan & Wei-Qing Chen, 2020. "Screen Exposure during Early Life and the Increased Risk of Astigmatism among Preschool Children: Findings from Longhua Child Cohort Study," IJERPH, MDPI, vol. 17(7), pages 1-13, March.
    2. Heba J. Sabbagh & Ghadeer Sharton & Jumana Almaghrabi & Manal Al-Malik & Mona Hassan Ahmed Hassan & Narmin Helal, 2021. "Effect of Environmental Tobacco Smoke on Children’s Anxiety and Behavior in Dental Clinics, Jeddah, Saudi Arabia: A Cross-Sectional Study," IJERPH, MDPI, vol. 18(1), pages 1-10, January.
    3. Ludmila Sevcikova & Jana Babjakova & Jana Jurkovicova & Martin Samohyl & Zuzana Stefanikova & Erika Machacova & Diana Vondrova & Etela Janekova & Katarina Hirosova & Alexandra Filova & Michael Weitzma, 2018. "Exposure to Environmental Tobacco Smoke in Relation to Behavioral, Emotional, Social and Health Indicators of Slovak School Children," IJERPH, MDPI, vol. 15(7), pages 1-13, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:10482-:d:895237. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.