IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9094-d872351.html
   My bibliography  Save this article

Association between Pre-Pregnancy Overweightness/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Author

Listed:
  • Szu-Ting Yang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan)

  • Chia-Hao Liu

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan)

  • Sheng-Hsiang Ma

    (Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Department of Dermatology, Taipei Veterans General Hospital, Taipei 112, Taiwan)

  • Wen-Hsun Chang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan)

  • Yi-Jen Chen

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan)

  • Wen-Ling Lee

    (Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Department of Medicine, Cheng-Hsin General Hospital, Taipei 112, Taiwan)

  • Peng-Hui Wang

    (Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
    Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan)

Abstract

Polycystic ovary syndrome (PCOS) is a common metabolic problem in women of reproductive age. Evidence suggests pregnant women with PCOS may have a higher risk of the development of adverse pregnancy outcomes; however, the relationship between pre-pregnancy overweight/obesity and pregnancy outcomes in women with PCOS remains uncertain. We try to clarify the relationship between pre-pregnancy overweight/obesity and subsequent pregnancy outcomes. Therefore, we conducted this systematic review and meta-analysis. We used the databases obtained from the PubMed, Embase, Web of Science, and Cochrane databases, plus hand-searching, to examine the association between pre-pregnancy overweightness/obesity and pregnancy outcomes in women with PCOS from inception to 4 February 2022. A total of 16 cohort studies, including 14 retrospective cohort studies ( n = 10,496) and another two prospective cohort studies ( n = 818), contributed to a total of 11,314 women for analysis. The meta-analysis showed significantly increased odds of miscarriage rate in PCOS women whose pre-pregnancy body mass index (BMI) is above overweight (OR 1.71 [95% CI 1.38–2.11]) or obese (OR 2.00 [95% CI 1.38–2.90]) under a random effect model. The tests for subgroup difference indicated the increased risk was consistent, regardless which body mass index cut-off for overweight (24 or 25 kg/m 2 ) or obesity (28 and 30 kg/m 2 ) was used. With the same strategies, we found that pregnant women in the control group significantly increased live birth rate compared with those pregnant women with PCOS as well as pre-pregnancy overweight/obesity (OR 0.79 [95% CI 0.71–0.89], OR 0.78 [95% CI 0.67–0.91]). By contrast, we did not find any association between PCOS women with pre-pregnancy overweight/obesity and preterm birth. Based on the aforementioned findings, the main critical factor contributing to a worse pregnancy outcome may be an early fetal loss in these PCOS women with pre-pregnancy overweight/obesity. Since PCOS women with pre-pregnancy overweightness/obesity were associated with worse pregnancy outcomes, we supposed that weight reduction before attempting pregnancy in the PCOS women with pre-pregnancy overweightness/obesity may improve the subsequent pregnancy outcomes.

Suggested Citation

  • Szu-Ting Yang & Chia-Hao Liu & Sheng-Hsiang Ma & Wen-Hsun Chang & Yi-Jen Chen & Wen-Ling Lee & Peng-Hui Wang, 2022. "Association between Pre-Pregnancy Overweightness/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(15), pages 1-16, July.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9094-:d:872351
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9094/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/15/9094/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Massimo Magrini & Olivia Curzio & Marco Tampucci & Gabriele Donzelli & Liliana Cori & Maria Cristina Imiotti & Sandra Maestro & Davide Moroni, 2022. "Anorexia Nervosa, Body Image Perception and Virtual Reality Therapeutic Applications: State of the Art and Operational Proposal," IJERPH, MDPI, vol. 19(5), pages 1-30, February.
    2. Romina Fakhraei & Kathryn Denize & Alexandre Simon & Ayni Sharif & Julia Zhu-Pawlowsky & Alysha L. J. Dingwall-Harvey & Brian Hutton & Misty Pratt & Becky Skidmore & Nadera Ahmadzai & Nicola Heslehurs, 2022. "Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review," IJERPH, MDPI, vol. 19(4), pages 1-23, February.
    3. Connor M. Sheehan & Esther E. Gotlieb & Stephanie L. Ayers & Daoqin Tong & Sabrina Oesterle & Sonia Vega-López & Wendy Wolfersteig & Dulce María Ruelas & Gabriel Q. Shaibi, 2022. "Neighborhood Conditions and Type 2 Diabetes Risk among Latino Adolescents with Obesity in Phoenix," IJERPH, MDPI, vol. 19(13), pages 1-18, June.
    4. Matthew B. Cooke & William Deasy & Elya J. Ritenis & Robin A. Wilson & Christos G. Stathis, 2022. "Effects of Intermittent Energy Restriction Alone and in Combination with Sprint Interval Training on Body Composition and Cardiometabolic Biomarkers in Individuals with Overweight and Obesity," IJERPH, MDPI, vol. 19(13), pages 1-17, June.
    5. Chia-Ho Lin & Yu-Hsuan Li & Ya-Yu Wang & Wen-Dau Chang, 2022. "Higher Neutrophil-To-Lymphocyte Ratio Was Associated with Increased Risk of Chronic Kidney Disease in Overweight/Obese but Not Normal-Weight Individuals," IJERPH, MDPI, vol. 19(13), pages 1-13, June.
    6. Mohammad Khursheed Alam & Ahmed Ali Alfawzan & Deepti Shrivastava & Kumar Chandan Srivastava & Haytham Jamil Alswairki & Samir Mussallam & Huda Abutayyem & Naseer Ahmed, 2022. "Oral Health Status in Marfan Syndrome: A Systematic Review and Meta-Analysis of 353 Cases," IJERPH, MDPI, vol. 19(9), pages 1-13, April.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Fadi G. Mirza & Muna A. Tahlak & Rachelle Bou Rjeili & Komal Hazari & Farah Ennab & Charlie Hodgman & Amar Hassan Khamis & William Atiomo, 2022. "Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?," IJERPH, MDPI, vol. 19(22), pages 1-15, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fadi G. Mirza & Muna A. Tahlak & Rachelle Bou Rjeili & Komal Hazari & Farah Ennab & Charlie Hodgman & Amar Hassan Khamis & William Atiomo, 2022. "Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?," IJERPH, MDPI, vol. 19(22), pages 1-15, November.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9094-:d:872351. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.