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Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review

Author

Listed:
  • Romina Fakhraei

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
    School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada)

  • Kathryn Denize

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Alexandre Simon

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Ayni Sharif

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Julia Zhu-Pawlowsky

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Alysha L. J. Dingwall-Harvey

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Brian Hutton

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
    School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada)

  • Misty Pratt

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Becky Skidmore

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Nadera Ahmadzai

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Nicola Heslehurst

    (Institute of Health & Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK)

  • Louise Hayes

    (Institute of Health & Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK)

  • Angela C. Flynn

    (Department of Women and Children’s Health, King’s College London, London WC2R 2LS, UK)

  • Maria P. Velez

    (Department of Obstetrics and Gynecology, Queen’s University, Kingston, ON K7L 3N6, Canada
    Department of Public Health Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada)

  • Graeme Smith

    (Department of Obstetrics and Gynecology, Queen’s University, Kingston, ON K7L 3N6, Canada
    Department of Public Health Sciences, Queen’s University, Kingston, ON K7L 3N6, Canada)

  • Andrea Lanes

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Natalie Rybak

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada)

  • Mark Walker

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
    School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
    Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada)

  • Laura Gaudet

    (Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
    Department of Obstetrics and Gynecology, Queen’s University, Kingston, ON K7L 3N6, Canada
    Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada
    Department of Obstetrics and Gynecology, Kingston Health Sciences Centre, Kingston, ON K7L 2V7, Canada)

Abstract

Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome ( n = 32), followed by preterm birth ( n = 29), preeclampsia ( n = 27), low birthweight infants ( n = 20), small for gestational age newborns ( n = 12), and stillbirth ( n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age < 20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.

Suggested Citation

  • Romina Fakhraei & Kathryn Denize & Alexandre Simon & Ayni Sharif & Julia Zhu-Pawlowsky & Alysha L. J. Dingwall-Harvey & Brian Hutton & Misty Pratt & Becky Skidmore & Nadera Ahmadzai & Nicola Heslehurs, 2022. "Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review," IJERPH, MDPI, vol. 19(4), pages 1-23, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:2063-:d:748148
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    Citations

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    Cited by:

    1. Fadi G. Mirza & Muna A. Tahlak & Rachelle Bou Rjeili & Komal Hazari & Farah Ennab & Charlie Hodgman & Amar Hassan Khamis & William Atiomo, 2022. "Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?," IJERPH, MDPI, vol. 19(22), pages 1-15, November.
    2. Szu-Ting Yang & Chia-Hao Liu & Sheng-Hsiang Ma & Wen-Hsun Chang & Yi-Jen Chen & Wen-Ling Lee & Peng-Hui Wang, 2022. "Association between Pre-Pregnancy Overweightness/Obesity and Pregnancy Outcomes in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(15), pages 1-16, July.

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