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Chronic Pesticide Exposure in Farm Workers Is Associated with the Epigenetic Modulation of hsa-miR-199a-5p

Author

Listed:
  • Giuseppe Gattuso

    (Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
    These authors contributed equally to this work.)

  • Luca Falzone

    (Epidemiology and Biostatistics Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131 Naples, Italy
    These authors contributed equally to this work.)

  • Chiara Costa

    (Clinical and Experimental Medicine Department, University of Messina, 98125 Messina, Italy)

  • Federica Giambò

    (CEMAD Digestive Disease Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy)

  • Michele Teodoro

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125 Messina, Italy)

  • Silvia Vivarelli

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125 Messina, Italy)

  • Massimo Libra

    (Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
    Research Centre for Prevention, Diagnosis, and Treatment of Cancer, University of Catania, 95123 Catania, Italy)

  • Concettina Fenga

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125 Messina, Italy)

Abstract

The increasing use of pesticides in intensive agriculture has had a negative impact on human health. It was widely demonstrated how pesticides can induce different genetic and epigenetic alterations associated with the development of different diseases, including tumors and neurological disorders. Therefore, the identification of effective indicators for the prediction of harmful pesticide exposure is mandatory. In this context, the aim of the study was to evaluate the modification of hsa-miR-199a-5p expression levels in liquid biopsy samples obtained from healthy donors and farm workers with chronic exposure to pesticides. For this purpose, the high-sensitive droplet digital PCR assay (ddPCR) was used to detect variation in the expression levels of the selected microRNA (miRNA). The ddPCR analyses revealed a significant down-regulation of hsa-miR-199a-5p observed in individuals exposed to pesticides compared to control samples highlighting the good predictive value of this miRNA as demonstrated by statistical analyses. Overall, the obtained results encourage the analysis of miRNAs as predictive biomarkers of chronic pesticide exposure thus improving the current strategies for the monitoring of harmful pesticide exposure.

Suggested Citation

  • Giuseppe Gattuso & Luca Falzone & Chiara Costa & Federica Giambò & Michele Teodoro & Silvia Vivarelli & Massimo Libra & Concettina Fenga, 2022. "Chronic Pesticide Exposure in Farm Workers Is Associated with the Epigenetic Modulation of hsa-miR-199a-5p," IJERPH, MDPI, vol. 19(12), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:7018-:d:834072
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    References listed on IDEAS

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    1. Muyesaier Tudi & Huada Daniel Ruan & Li Wang & Jia Lyu & Ross Sadler & Des Connell & Cordia Chu & Dung Tri Phung, 2021. "Agriculture Development, Pesticide Application and Its Impact on the Environment," IJERPH, MDPI, vol. 18(3), pages 1-23, January.
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