IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2021i1p42-d707870.html
   My bibliography  Save this article

Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

Author

Listed:
  • Jasmina Grujić

    (Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
    Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Nevenka Bujandrić

    (Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
    Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Zorana Budakov-Obradović

    (Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
    Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Vladimir Dolinaj

    (Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia
    Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia)

  • Damir Bogdan

    (Social Sciences and Computing, University of Belgrade, 11000 Belgrade, Serbia)

  • Nebojša Savić

    (Transfusion Medicine Department, Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia)

  • Alejandro Cabezas-Cruz

    (Anses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France)

  • Dragana Mijatović

    (Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia)

  • Verica Simin

    (Department of Microbiology, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia)

  • Nikola Anđelić

    (Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Pavle Banović

    (Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia
    Department of Microbiology with Parasitology and Immunology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

Abstract

Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals ( n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals ( p = 0.034), older age groups ( p < 0.001), existence of hypertension ( p = 0.008), and severe COVID-19 ( p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity.

Suggested Citation

  • Jasmina Grujić & Nevenka Bujandrić & Zorana Budakov-Obradović & Vladimir Dolinaj & Damir Bogdan & Nebojša Savić & Alejandro Cabezas-Cruz & Dragana Mijatović & Verica Simin & Nikola Anđelić & Pavle Ban, 2021. "Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors," IJERPH, MDPI, vol. 19(1), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:42-:d:707870
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/1/42/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/1/42/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Michael Zietz & Jason Zucker & Nicholas P. Tatonetti, 2020. "Associations between blood type and COVID-19 infection, intubation, and death," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
    2. Katie L. Kunze & Patrick W. Johnson & Noud Helmond & Jonathon W. Senefeld & Molly M. Petersen & Stephen A. Klassen & Chad C. Wiggins & Allan M. Klompas & Katelyn A. Bruno & John R. Mills & Elitza S. T, 2021. "Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors," Nature Communications, Nature, vol. 12(1), pages 1-6, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gonnet, Gaston H. & Stewart, John & Lafleur, Joseph & Keith, Stephen & McLellan, Mark & Jiang-Gorsline, David & Snider, Tim, 2021. "Analysis of feature influence on Covid-19 Death Rate Per Country Using a Novel Orthogonalization Technique," MetaArXiv 4kw2n, Center for Open Science.
    2. Nagla A. El-Shitany & Manal El-Hamamsy & Ahlam A. Alahmadi & Basma G. Eid & Thikryat Neamatallah & Haifa S. Almukadi & Rana A. Arab & Khadija A. Faddladdeen & Khayria A. Al-Sulami & Safia M. Bahshwan , 2021. "The Impact of ABO Blood Grouping on COVID-19 Vulnerability and Seriousness: A Retrospective Cross-Sectional Controlled Study among the Arab Community," IJERPH, MDPI, vol. 18(1), pages 1-19, January.
    3. Salvador Domènech-Montoliu & Joan Puig-Barberà & Maria Rosario Pac-Sa & Paula Vidal-Utrillas & Marta Latorre-Poveda & Alba Del Rio-González & Sara Ferrando-Rubert & Gema Ferrer-Abad & Manuel Sánchez-U, 2021. "ABO Blood Groups and the Incidence of Complications in COVID-19 Patients: A Population-Based Prospective Cohort Study," IJERPH, MDPI, vol. 18(19), pages 1-13, September.
    4. Willem Boterman, 2023. "Population density and SARS-CoV-2 pandemic: Comparing the geography of different waves in the Netherlands," Urban Studies, Urban Studies Journal Limited, vol. 60(8), pages 1377-1402, June.
    5. Gabriela Macedo-Ojeda & José Francisco Muñoz-Valle & Patricia Yokogawa-Teraoka & Andrea Carolina Machado-Sulbarán & María Guadalupe Loza-Rojas & Atziri Citlally García-Arredondo & Rafael Tejeda-Consta, 2021. "COVID-19 Screening by Anti-SARS-CoV-2 Antibody Seropositivity: Clinical and Epidemiological Characteristics, Comorbidities, and Food Intake Quality," IJERPH, MDPI, vol. 18(17), pages 1-13, August.
    6. Yvonne M. Mueller & Thijs J. Schrama & Rik Ruijten & Marco W. J. Schreurs & Dwin G. B. Grashof & Harmen J. G. van de Werken & Giovanna Jona Lasinio & Daniel Álvarez-Sierra & Caoimhe H. Kiernan & Melis, 2022. "Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:42-:d:707870. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.