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Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

Author

Listed:
  • Jasmina Grujić

    (Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
    Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Nevenka Bujandrić

    (Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
    Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Zorana Budakov-Obradović

    (Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
    Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Vladimir Dolinaj

    (Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia
    Department of Anesthesia and Intensive Care, Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia)

  • Damir Bogdan

    (Social Sciences and Computing, University of Belgrade, 11000 Belgrade, Serbia)

  • Nebojša Savić

    (Transfusion Medicine Department, Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia)

  • Alejandro Cabezas-Cruz

    (Anses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France)

  • Dragana Mijatović

    (Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia)

  • Verica Simin

    (Department of Microbiology, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia)

  • Nikola Anđelić

    (Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

  • Pavle Banović

    (Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia
    Department of Microbiology with Parasitology and Immunology, Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia)

Abstract

Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals ( n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals ( p = 0.034), older age groups ( p < 0.001), existence of hypertension ( p = 0.008), and severe COVID-19 ( p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity.

Suggested Citation

  • Jasmina Grujić & Nevenka Bujandrić & Zorana Budakov-Obradović & Vladimir Dolinaj & Damir Bogdan & Nebojša Savić & Alejandro Cabezas-Cruz & Dragana Mijatović & Verica Simin & Nikola Anđelić & Pavle Ban, 2021. "Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors," IJERPH, MDPI, vol. 19(1), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:19:y:2021:i:1:p:42-:d:707870
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    References listed on IDEAS

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    1. Katie L. Kunze & Patrick W. Johnson & Noud Helmond & Jonathon W. Senefeld & Molly M. Petersen & Stephen A. Klassen & Chad C. Wiggins & Allan M. Klompas & Katelyn A. Bruno & John R. Mills & Elitza S. T, 2021. "Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors," Nature Communications, Nature, vol. 12(1), pages 1-6, December.
    2. Michael Zietz & Jason Zucker & Nicholas P. Tatonetti, 2020. "Associations between blood type and COVID-19 infection, intubation, and death," Nature Communications, Nature, vol. 11(1), pages 1-6, December.
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