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Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo

Author

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  • Didier Malamba-Lez

    (Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo
    Doctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium)

  • Désire Tshala-Katumbay

    (Department of Neurology and School of Public Health, Oregon Health & Science University, Portland, OR 97007, USA)

  • Virginie Bito

    (Doctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium)

  • Jean-Michel Rigo

    (Doctoral School for Medicine and Life Sciences, Hasselt University, 3590 Diepenbeek, Belgium)

  • Richie Kipenge Kyandabike

    (Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo)

  • Eric Ngoy Yolola

    (Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo)

  • Philippe Katchunga

    (Department of Internal Medicine, Official University of Bukavu, Bukavu 11102, Democratic Republic of the Congo)

  • Béatrice Koba-Bora

    (Department of Internal Medicine, Service of Neurology, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo)

  • Dophra Ngoy-Nkulu

    (Unit of Training and Research in Cardiology, Department of Internal Medicine, University of Lubumbashi, Lubumbashi 07610, Democratic Republic of the Congo)

Abstract

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in μg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.

Suggested Citation

  • Didier Malamba-Lez & Désire Tshala-Katumbay & Virginie Bito & Jean-Michel Rigo & Richie Kipenge Kyandabike & Eric Ngoy Yolola & Philippe Katchunga & Béatrice Koba-Bora & Dophra Ngoy-Nkulu, 2021. "Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo," IJERPH, MDPI, vol. 18(9), pages 1-21, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:9:p:4956-:d:549785
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    References listed on IDEAS

    as
    1. Jinyao Mo & Yajuan Xia & Timothy J. Wade & David M. DeMarini & Mercy Davidson & Judy Mumford, 2011. "Altered Gene Expression by Low-Dose Arsenic Exposure in Humans and Cultured Cardiomyocytes: Assessment by Real-Time PCR Arrays," IJERPH, MDPI, vol. 8(6), pages 1-19, June.
    2. Célestin Banza Lubaba Nkulu & Lidia Casas & Vincent Haufroid & Thierry De Putter & Nelly D. Saenen & Tony Kayembe-Kitenge & Paul Musa Obadia & Daniel Kyanika Wa Mukoma & Jean-Marie Lunda Ilunga & Tim , 2018. "Sustainability of artisanal mining of cobalt in DR Congo," Nature Sustainability, Nature, vol. 1(9), pages 495-504, September.
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    Cited by:

    1. Jens Bertram & Christian Ramolla & André Esser & Thomas Schettgen & Nina Fohn & Thomas Kraus, 2022. "Blood Lead Monitoring in a Former Mining Area in Euskirchen, Germany—Volunteers across the Entire Population," IJERPH, MDPI, vol. 19(10), pages 1-15, May.

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