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Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data

Author

Listed:
  • Miguel Ángel Hernández-Rodríguez

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Dirección del Servicio Canario de la Salud, Plan de Salud de Canarias, ES-38004 Santa Cruz de Tenerife, Spain)

  • Ermengol Sempere-Verdú

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud de Paterna, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, ES-46980 Valencia, Spain)

  • Caterina Vicens-Caldentey

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud Son Serra-La Vileta, Servicio de Salud de las Islas Baleares Ib-salut, ES-07013 Palma, Spain
    Institut d’Investigació Sanitaria Illes Balears (IDISBA), Servicio de Salud de las Islas Baleares Ib-salut, ES-07120 Palma de Mallorca, Spain)

  • Francisca González-Rubio

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud Delicias Sur, Servicio Aragonés de Salud, ES-50009 Zaragoza, Spain
    EpiChron Research Group on Chronic Diseases, Aragon Health Research Institute (IIS Aragón), ES-50009 Zaragoza, Spain)

  • Félix Miguel-García

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Ministerio de Sanidad, Consumo y Bienestar Social, ES-28014 Madrid, Spain)

  • Vicente Palop-Larrea

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Hospital de Denia. Marina Salud, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, ES-03700 Alicante, Spain)

  • Ramón Orueta-Sánchez

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud de Sillería, Servicio de Salud de Castilla-La Mancha, ES-45001 Toledo, Spain)

  • Óscar Esteban-Jiménez

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud de Sádaba, Servicio Aragonés de Salud, ES-50670 Zaragoza, Spain)

  • Mara Sempere-Manuel

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud de Sueca, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, ES-46410 Valencia, Spain)

  • María Pilar Arroyo-Aniés

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud de Huarte, Servicio Navarro de Salud, ES-31620 Pamplona, Spain)

  • Buenaventura Fernández-San José

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Centro de Salud de Canalejas, Servicio Canario de la Salud, ES-35004 Las Palmas de Gran Canaria, Spain)

  • José Ignacio de Juan-Roldán

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    Departamento de Farmacología y Pediatría, Facultad de Medicina, Universidad de Málaga, ES-29010 Málaga, Spain)

  • Ignatios Ioakeim-Skoufa

    (Drug Utilization Work Group, Spanish Society of Family and Community Medicine (semFYC), ES-08009 Barcelona, Spain
    EpiChron Research Group on Chronic Diseases, Aragon Health Research Institute (IIS Aragón), ES-50009 Zaragoza, Spain
    Vaksinasjonssenter BSN, Bydel Søndre Nordstrand, Oslo kommune, NO-1252 Oslo, Norway)

Abstract

We aimed to identify and compare medication profiles in populations with polypharmacy between 2005 and 2015. We conducted a cross-sectional study using information from the Computerized Database for Pharmacoepidemiologic Studies in Primary Care (BIFAP, Spain). We estimated the prevalence of therapeutic subgroups in all individuals 15 years of age and older with polypharmacy (≥5 drugs during ≥6 months) using the Anatomical Therapeutic Chemical classification system level 4, by sex and age group, for both calendar years. The most prescribed drugs were proton-pump inhibitors (PPIs), statins, antiplatelet agents, benzodiazepine derivatives, and angiotensin-converting enzyme inhibitors. The greatest increases between 2005 and 2015 were observed in PPIs, statins, other antidepressants, and β-blockers, while the prevalence of antiepileptics was almost tripled. We observed increases in psychotropic drugs in women and cardiovascular medications in men. By patient´s age groups, there were notable increases in antipsychotics, antidepressants, and antiepileptics (15–44 years); antidepressants, PPIs, and selective β-blockers (45–64 years); selective β-blockers, biguanides, PPIs, and statins (65–79 years); and in statins, selective β-blockers, and PPIs (80 years and older). Our results revealed important increases in the use of specific therapeutic subgroups, like PPIs, statins, and psychotropic drugs, highlighting opportunities to design and implement strategies to analyze such prescriptions’ appropriateness.

Suggested Citation

  • Miguel Ángel Hernández-Rodríguez & Ermengol Sempere-Verdú & Caterina Vicens-Caldentey & Francisca González-Rubio & Félix Miguel-García & Vicente Palop-Larrea & Ramón Orueta-Sánchez & Óscar Esteban-Jim, 2021. "Drug Prescription Profiles in Patients with Polypharmacy in Spain: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data," IJERPH, MDPI, vol. 18(9), pages 1-10, April.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:9:p:4754-:d:546206
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    References listed on IDEAS

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    1. Ignatios Ioakeim-Skoufa & Beatriz Poblador-Plou & Jonás Carmona-Pírez & Jesús Díez-Manglano & Rokas Navickas & Luis Andrés Gimeno-Feliu & Francisca González-Rubio & Elena Jureviciene & Laimis Dambraus, 2020. "Multimorbidity Patterns in the General Population: Results from the EpiChron Cohort Study," IJERPH, MDPI, vol. 17(12), pages 1-15, June.
    2. Carmen Rodriguez-Blazquez & Maria João Forjaz & Antonio Gimeno-Miguel & Kevin Bliek-Bueno & Beatriz Poblador-Plou & Sara Pilar Luengo-Broto & Inmaculada Guerrero-Fernández de Alba & Ana Maria Carriazo, 2020. "Assessing the Pilot Implementation of the Integrated Multimorbidity Care Model in Five European Settings: Results from the Joint Action CHRODIS-PLUS," IJERPH, MDPI, vol. 17(15), pages 1-14, July.
    3. Dedan Opondo & Saied Eslami & Stefan Visscher & Sophia E de Rooij & Robert Verheij & Joke C Korevaar & Ameen Abu-Hanna, 2012. "Inappropriateness of Medication Prescriptions to Elderly Patients in the Primary Care Setting: A Systematic Review," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-9, August.
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    Cited by:

    1. Ignatios Ioakeim-Skoufa & Mercedes Clerencia-Sierra & Aida Moreno-Juste & Carmen Elías de Molins Peña & Beatriz Poblador-Plou & Mercedes Aza-Pascual-Salcedo & Francisca González-Rubio & Alexandra Prad, 2022. "Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    2. Xisco Reus & Maria Lluisa Sastre & Alfonso Leiva & Belén Sánchez & Cristina García-Serra & Ignatios Ioakeim-Skoufa & Caterina Vicens, 2022. "LESS-PHARMA Study: Identifying and Deprescribing Potentially Inappropriate Medication in the Elderly Population with Excessive Polypharmacy in Primary Care," IJERPH, MDPI, vol. 19(20), pages 1-10, October.

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