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Nicotine Replacement Therapy during Pregnancy and Child Health Outcomes: A Systematic Review

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  • Julie Blanc

    (Department of Obstetrics and Gynecology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France
    EA3279, CEReSS, Health Service Research and Quality of Life Center, Aix-Marseille University, 13284 Marseille, France)

  • Barthélémy Tosello

    (Department of Neonatology, North Hospital, Assistance Publique des Hôpitaux de Marseille, 13015 Marseille, France
    CNRS, EFS, ADES, Aix-Marseille University, 13284 Marseille, France)

  • Mikael O. Ekblad

    (Department of General Practice, Institute of Medicine, Turku University, Turku University Hospital, 20014 Turku, Finland)

  • Ivan Berlin

    (Department of Pharmacology, Assistance Publique-Hôpitaux de Paris, Sorbonne University, 75013 Paris, France
    University Centre of General Medicine and Public Health, 1011 Lausanne, Switzerland)

  • Antoine Netter

    (Department of Obstetrics and Gynecology, North Hospital, APHM, Chemin des Bourrely, 13015 Marseille, France
    Institut Méditerranéen de Biodiversité et d’Écologie Marine et Continentale (IMBE), Aix Marseille University, CNRS, IRD, Avignon University, 13003 Marseille, France)

Abstract

Tobacco smoking in pregnancy is a worldwide public health problem. A majority of pregnant smokers need assistance to stop smoking. Most scientific societies recommend nicotine replacement therapy (NRT) during pregnancy but this recommendation remains controversial because of the known fetal toxicity of nicotine. The objective of this systematic review was to provide an overview of human studies about child health outcomes associated with NRT use during pregnancy. The electronic databases MEDLINE, the Cochrane Database, Web of Science, and ClinicalTrials.gov were searched from the inception of each database until 26 December 2020. A total of 103 articles were identified through database searching using combination of keywords. Out of 75 screened articles and after removal of duplicates, ten full-text articles were assessed for eligibility and five were included in the qualitative synthesis. NRT prescription seems to be associated with higher risk of infantile colic at 6 months as in case of smoking during pregnancy, and with risk of attention-deficit/hyperactivity disorder. No association between NRT during pregnancy and other infant health disorders or major congenital anomalies has been reported. Well-designed controlled clinical trials with sufficient follows-up are needed to provide more information on the use of NRT or other pharmacotherapies for smoking cessation during pregnancy on post-natal child health outcomes.

Suggested Citation

  • Julie Blanc & Barthélémy Tosello & Mikael O. Ekblad & Ivan Berlin & Antoine Netter, 2021. "Nicotine Replacement Therapy during Pregnancy and Child Health Outcomes: A Systematic Review," IJERPH, MDPI, vol. 18(8), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4004-:d:533953
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    Cited by:

    1. María Morales-Suárez-Varela & Beatriz Marcos Puig & Linda Kaerlev & Isabel Peraita-Costa & Alfredo Perales-Marín, 2022. "Safety of Nicotine Replacement Therapy during Pregnancy: A Narrative Review," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    2. Mikael O. Ekblad & Julie Blanc & Ivan Berlin, 2021. "Special Issue on the Effects of Prenatal Smoking/Nicotine Exposure on the Child’s Health," IJERPH, MDPI, vol. 18(10), pages 1-4, May.

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