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Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

Author

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  • Luís Azevedo

    (Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain
    Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal)

  • André Correia

    (Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal)

  • Carlos F. Almeida

    (Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal
    Department of Oral Rehabilitation, Universidade do Porto, 4200 Oporto, Portugal)

  • Pedro Molinero-Mourelle

    (Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain
    Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, 3010 Bern, Switzerland)

  • Maria Correia

    (Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Universidade Católica Portuguesa, 3504 Viseu, Portugal)

  • Jaime Del Río Highsmith

    (Department of Conservative Dentistry and Orofacial Prosthodontics, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain)

Abstract

To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives ( p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness ( p = 0.001), and the control reported better results in taste ( p = 0.03) and in chewing ( p = 0.001). The test adhesive showed better ( p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans . Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.

Suggested Citation

  • Luís Azevedo & André Correia & Carlos F. Almeida & Pedro Molinero-Mourelle & Maria Correia & Jaime Del Río Highsmith, 2021. "Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial," IJERPH, MDPI, vol. 18(7), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:7:p:3398-:d:523880
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    References listed on IDEAS

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    1. Kenneth F Schulz & Douglas G Altman & David Moher & for the CONSORT Group, 2010. "CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-7, March.
    2. Gianna Maria Nardi & Sara Fais & Cinzia Casu & Marta Mazur & Roberto Di Giorgio & Roberta Grassi & Felice Roberto Grassi & Germano Orrù, 2020. "Mouthwash Based on Ozonated Olive Oil in Caries Prevention: A Preliminary In-Vitro Study," IJERPH, MDPI, vol. 17(23), pages 1-9, December.
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