IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i6p3045-d517766.html
   My bibliography  Save this article

Obstructive Sleep Apnea, Palatal Morphology, and Aortic Dilatation in Marfan Syndrome Growing Subjects: A Retrospective Study

Author

Listed:
  • Giuseppina Laganà

    (Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Nicolò Venza

    (Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Arianna Malara

    (Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Claudio Liguori

    (Sleep Medicine Centre, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Paola Cozza

    (Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Calogera Pisano

    (Centre for Rare Diseases for Marfan Syndrome and Related Disorders, Department of Cardiac Surgery Unit, University of Tor Vergata General Hospital, 00133 Rome, Italy)

Abstract

The main cause of mortality in Marfan syndrome (MS) is aortic disease. Obstructive sleep apnea (OSA) is highly prevalent in MS, and it is also associated with cardiovascular risk and maxillary deformities. The aim of this research was to analyze the possible relations between OSA, palatal morphology, and aortic root diameters in growing subjects. A group of 15 growing subjects with MS and a control group of healthy peers was selected. All of them underwent nocturnal polygraphic monitoring, digital dental casts, and transthoracic echocardiography. The results showed that OSA indexes and aortic diameters were significantly higher in the study group. Transversal palatal dimension was smaller in MS patients. Moreover, OSA severity was not related with maxillary contraction severity in MS. No correlation between OSA severity and increased aortic diameters occurred. A high prevalence of OSA, increased aortic dimensions, and significant contraction of palatal dimensions were observed in MS compared with the control group. None of these single factors may directly be associated with aortic dilation, but together, they might contribute to the development and progression of aortic aneurysm from a young age.

Suggested Citation

  • Giuseppina Laganà & Nicolò Venza & Arianna Malara & Claudio Liguori & Paola Cozza & Calogera Pisano, 2021. "Obstructive Sleep Apnea, Palatal Morphology, and Aortic Dilatation in Marfan Syndrome Growing Subjects: A Retrospective Study," IJERPH, MDPI, vol. 18(6), pages 1-10, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3045-:d:517766
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/6/3045/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/6/3045/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Hiroshi Kimura & Hiroyo Ota & Yuya Kimura & Shin Takasawa, 2019. "Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases," IJERPH, MDPI, vol. 16(17), pages 1-13, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Miriam Fioravanti & Francesca Zara & Iole Vozza & Antonella Polimeni & Gian Luca Sfasciotti, 2021. "The Efficacy of Lingual Laser Frenectomy in Pediatric OSAS: A Randomized Double-Blinded and Controlled Clinical Study," IJERPH, MDPI, vol. 18(11), pages 1-13, June.
    2. Agnieszka Trawicka & Aleksandra Lewandowska-Walter & Mikołaj Majkowicz & Robert Sabiniewicz & Lidia Woźniak-Mielczarek, 2022. "Health-Related Quality of Life of Patients with Marfan Syndrome—Polish Study," IJERPH, MDPI, vol. 19(11), pages 1-12, June.
    3. Nicolò Venza & Giulia Alloisio & Magda Gioia & Claudio Liguori & Annarita Nappi & Carlotta Danesi & Giuseppina Laganà, 2022. "Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients," IJERPH, MDPI, vol. 19(20), pages 1-7, October.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chiara Stipa & Serena Incerti-Parenti & Matteo Cameli & Daniela Rita Ippolito & Antonio Gracco & Giulio Alessandri-Bonetti, 2023. "Antero-Posterior Mandibular Excursion in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Device: A Retrospective Cohort Study," IJERPH, MDPI, vol. 20(4), pages 1-9, February.
    2. Hai-Hua Chuang & Jen-Fu Hsu & Chao-Yung Wang & Li-Pang Chuang & Min-Chi Chen & Ning-Hung Chen & Yu-Shu Huang & Hsueh-Yu Li & Li-Ang Lee, 2021. "Hypertension in Children with Obstructive Sleep Apnea Syndrome—Age, Weight Status, and Disease Severity," IJERPH, MDPI, vol. 18(18), pages 1-17, September.
    3. Nicolò Venza & Giulia Alloisio & Magda Gioia & Claudio Liguori & Annarita Nappi & Carlotta Danesi & Giuseppina Laganà, 2022. "Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients," IJERPH, MDPI, vol. 19(20), pages 1-7, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:3045-:d:517766. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.