IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i17p3101-d261143.html
   My bibliography  Save this article

Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases

Author

Listed:
  • Hiroshi Kimura

    (Department of Advanced Medicine for Pulmonary Circulation and Respiratory Failure, Graduate School of Medicine, Nippon Medical School, Bunkyo, Tokyo 113-8603, Japan)

  • Hiroyo Ota

    (Department of Respiratory Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan)

  • Yuya Kimura

    (Center for Pulmonary Diseases, NHO Tokyo National Hospital, Kiyose, Tokyo 204-0023, Japan)

  • Shin Takasawa

    (Department of Biochemistry, Nara Medical University, Kashihara, Nara 634-8521, Japan)

Abstract

Obstructive sleep apnea (OSA) causes many systemic disorders via mechanisms related to sympathetic nerve activation, systemic inflammation, and oxidative stress. OSA typically shows repeated sleep apnea followed by hyperventilation, which results in intermittent hypoxia (IH). IH is associated with an increase in sympathetic activity, which is a well-known pathophysiological mechanism in hypertension and insulin resistance. In this review, we show the basic and clinical significance of IH from the viewpoint of not only systemic regulatory mechanisms focusing on pulmonary circulation, but also cellular mechanisms causing lifestyle-related diseases. First, we demonstrate how IH influences pulmonary circulation to cause pulmonary hypertension during sleep in association with sleep state-specific change in OSA. We also clarify how nocturnal IH activates circulating monocytes to accelerate the infiltration ability to vascular wall in OSA. Finally, the effects of IH on insulin secretion and insulin resistance are elucidated by using an in vitro chamber system that can mimic and manipulate IH. The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic β cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-α, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Clinical and experimental findings concerning IH give us productive new knowledge of how lifestyle-related diseases and pulmonary hypertension develop during sleep.

Suggested Citation

  • Hiroshi Kimura & Hiroyo Ota & Yuya Kimura & Shin Takasawa, 2019. "Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases," IJERPH, MDPI, vol. 16(17), pages 1-13, August.
  • Handle: RePEc:gam:jijerp:v:16:y:2019:i:17:p:3101-:d:261143
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/17/3101/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/16/17/3101/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Giuseppina Laganà & Nicolò Venza & Arianna Malara & Claudio Liguori & Paola Cozza & Calogera Pisano, 2021. "Obstructive Sleep Apnea, Palatal Morphology, and Aortic Dilatation in Marfan Syndrome Growing Subjects: A Retrospective Study," IJERPH, MDPI, vol. 18(6), pages 1-10, March.
    2. Chiara Stipa & Serena Incerti-Parenti & Matteo Cameli & Daniela Rita Ippolito & Antonio Gracco & Giulio Alessandri-Bonetti, 2023. "Antero-Posterior Mandibular Excursion in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Device: A Retrospective Cohort Study," IJERPH, MDPI, vol. 20(4), pages 1-9, February.
    3. Hai-Hua Chuang & Jen-Fu Hsu & Chao-Yung Wang & Li-Pang Chuang & Min-Chi Chen & Ning-Hung Chen & Yu-Shu Huang & Hsueh-Yu Li & Li-Ang Lee, 2021. "Hypertension in Children with Obstructive Sleep Apnea Syndrome—Age, Weight Status, and Disease Severity," IJERPH, MDPI, vol. 18(18), pages 1-17, September.
    4. Nicolò Venza & Giulia Alloisio & Magda Gioia & Claudio Liguori & Annarita Nappi & Carlotta Danesi & Giuseppina Laganà, 2022. "Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients," IJERPH, MDPI, vol. 19(20), pages 1-7, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:17:p:3101-:d:261143. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.