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The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma

Author

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  • Yao-Chen Wang

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Shih-Ming Tsao

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Yia-Ting Li

    (Division of Respiratory Therapy, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan)

  • Chia-Yi Lee

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan)

  • Thomas Chang-Yao Tsao

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Ming-Ju Hsieh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

The aim of the current study is to investigate potential associations among Long Noncoding RNA (LncRNA) H19 single nucleotide polymorphism (SNP) and epidermal growth factor receptor (EGFR) phenotypes on the clinicopathological characteristics of lung adenocarcinoma (LADC). Five loci of LncRNA H19 SNPs (rs217727, rs2107425, rs2839698, rs3024270, and rs3741219) were genotyped by using TaqMan allelic discrimination in 223 LADC patients with wild-type EGFR phenotype and 323 LADC individuals with EGFR mutations. After the statistical analyses, patients with the EGFR mutation were related to a higher distribution frequency of rs217727 SNP CT heterozygote ( p = 0.030), and the female population with EGFR mutation demonstrated a higher distribution frequency of rs217727 SNP CT heterozygote ( p < 0.001) and rs2107425 CT heterozygote ( p = 0.002). In addition, the presence of LncRNA H19 SNP rs217727 T allele (CT + TT) in patients with EGFR wild-type was associated to higher tumor T status (stage III or IV, p = 0.037) and poorer cell differentiation status (poor differentiation, p = 0.012) compared to those EGFR wild-type individuals with LncRNA H19 SNP rs217727 CC allele. Besides, a prominently higher tumor T status was found in subjects with LncRNA H19 SNP rs2107425 T allele (CT + TT) (stage III or IV, p = 0.007) compared to EGFR wild-type LADC individuals with LncRNA CC allele in EGFR wild-type patients. Our findings suggest that the presence of LncRNA H19 SNP rs217727 is related to the EGFR mutation in LADC patients, and the LncRNA H19 SNP rs217727 and rs2107425 are associated with progressed tumor status for LADC patients with EGFR wild-type.

Suggested Citation

  • Yao-Chen Wang & Shih-Ming Tsao & Yia-Ting Li & Chia-Yi Lee & Thomas Chang-Yao Tsao & Ming-Ju Hsieh & Shun-Fa Yang, 2021. "The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma," IJERPH, MDPI, vol. 18(6), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:6:p:2862-:d:515135
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    References listed on IDEAS

    as
    1. Po-Jen Yang & Ming-Ju Hsieh & Chun-I Lee & Chi-Hua Yen & Hsiang-Ling Wang & Whei-Ling Chiang & Tu-Chen Liu & Thomas Chang-Yao Tsao & Chia-Yi Lee & Shun-Fa Yang, 2020. "Impact of Aurora Kinase A Polymorphism and Epithelial Growth Factor Receptor Mutations on the Clinicopathological Characteristics of Lung Adenocarcinoma," IJERPH, MDPI, vol. 17(19), pages 1-11, October.
    2. Po-Jen Yang & Ming-Ju Hsieh & Tung-Wei Hung & Shian-Shiang Wang & Shiuan-Chih Chen & Meng-Chih Lee & Shun-Fa Yang & Ying-Erh Chou, 2019. "Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development," IJERPH, MDPI, vol. 16(8), pages 1-10, April.
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    Cited by:

    1. Sunny Li-Yun Chang & Po-Jen Yang & Yen-You Lin & Ya-Jing Jiang & Po-I Liu & Chang-Lun Huang & Shun-Fa Yang & Chih-Hsin Tang, 2022. "Genetic Associations of Visfatin Polymorphisms with EGFR Status and Clinicopathologic Characteristics in Lung Adenocarcinoma," IJERPH, MDPI, vol. 19(22), pages 1-11, November.
    2. Ming-Hong Hsieh & Yi-Liang Wu & Thomas Chang-Yao Tsao & Yi-Wen Huang & Jian-Cheng Lin & Chia-Yi Lee & Ming-Ju Hsieh & Shun-Fa Yang, 2022. "Impact of LncRNA GAS5 Genetic Variants and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma Patients," IJERPH, MDPI, vol. 19(16), pages 1-9, August.

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    More about this item

    Keywords

    long noncoding RNA H19; epithelial growth factor receptor; lung adenocarcinoma; single nucleotide polymorphism; tumor status;
    All these keywords.

    JEL classification:

    • H19 - Public Economics - - Structure and Scope of Government - - - Other

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