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Impact of LncRNA GAS5 Genetic Variants and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma Patients

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  • Ming-Hong Hsieh

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Psychiatry, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Yi-Liang Wu

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Surgery, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Thomas Chang-Yao Tsao

    (Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Yi-Wen Huang

    (Department of Health, Pulmonary and Critical Care Unit, Changhua Hospital, Changhua 513, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan)

  • Jian-Cheng Lin

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Chia-Yi Lee

    (Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Nobel Eye Institute, Taipei 115, Taiwan)

  • Ming-Ju Hsieh

    (Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

The aim of the current study was to evaluate the combined effect of the single nucleotide polymorphism (SNP) in long non-coding RNA growth arrest-specific 5 (GAS5) and the phenotypes of epidermal growth factor receptor (EGFR) on the clinicopathological characteristics of lung adenocarcinoma. The present study examined the relationship between the GAS5 single-nucleotide polymorphisms (SNPs; rs145204276 Ins/Del, rs55829688 T/C) and the clinicopathological factors in 539 lung adenocarcinoma patients with or without EGFR mutations. We found that the genotype distributions of the two GAS5 SNPs between different EGFR genotypes were similar after adjusting for age, gender and smoking history. The GAS5 SNP rs145204276 Ins/Del + Del/Del illustrated a higher distribution with an advanced tumor stage ( p = 0.030), larger tumor T status ( p = 0.019), positive lymph node status ( p = 0.014) and distal metastases ( p = 0.011) in the EGFR wild type group. In the subgroup analysis of the EGFR wild type population, the presence of GAS5 SNP rs145204276 Ins/Del + Del/Del was correlated to an advanced tumor stage ( p = 0.014) and distal metastases ( p = 0.020) in non-smokers. In conclusion, these data indicate that the GAS5 SNP rs145204276 variant may help predict tumor stage, lymph node metastasis and distal metastases in patients with EGFR wild type lung adenocarcinoma.

Suggested Citation

  • Ming-Hong Hsieh & Yi-Liang Wu & Thomas Chang-Yao Tsao & Yi-Wen Huang & Jian-Cheng Lin & Chia-Yi Lee & Ming-Ju Hsieh & Shun-Fa Yang, 2022. "Impact of LncRNA GAS5 Genetic Variants and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma Patients," IJERPH, MDPI, vol. 19(16), pages 1-9, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:9971-:d:886831
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    References listed on IDEAS

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    1. Po-Jen Yang & Ming-Ju Hsieh & Chun-I Lee & Chi-Hua Yen & Hsiang-Ling Wang & Whei-Ling Chiang & Tu-Chen Liu & Thomas Chang-Yao Tsao & Chia-Yi Lee & Shun-Fa Yang, 2020. "Impact of Aurora Kinase A Polymorphism and Epithelial Growth Factor Receptor Mutations on the Clinicopathological Characteristics of Lung Adenocarcinoma," IJERPH, MDPI, vol. 17(19), pages 1-11, October.
    2. Yao-Chen Wang & Shih-Ming Tsao & Yia-Ting Li & Chia-Yi Lee & Thomas Chang-Yao Tsao & Ming-Ju Hsieh & Shun-Fa Yang, 2021. "The Relationship between Long Noncoding RNA H19 Polymorphism and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma," IJERPH, MDPI, vol. 18(6), pages 1-12, March.
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    Keywords

    lung cancer; GAS5; polymorphism; EGFR mutation;
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